1996-41-4 Usage
Description
2-Chloro-4-fluorophenol is an organic compound characterized by its light yellow liquid appearance. It is a derivative of phenol, featuring a chlorine atom at the 2nd position and a fluorine atom at the 4th position on the benzene ring. 2-Chloro-4-fluorophenol is known for its unique chemical properties and potential applications in various industries.
Uses
Used in Enzymatic Production:
2-Chloro-4-fluorophenol is used as a key intermediate in the enzymatic production of fluorocatechols. These fluorocatechols are valuable building blocks in the synthesis of various pharmaceuticals, agrochemicals, and other specialty chemicals. The use of 2-Chloro-4-fluorophenol in this process allows for the creation of these important compounds with higher efficiency and selectivity.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 2-Chloro-4-fluorophenol is utilized as a starting material for the synthesis of various drugs and drug candidates. Its unique structure and reactivity make it a valuable component in the development of new medications, particularly those targeting specific biological pathways or receptors.
Used in Agrochemical Industry:
2-Chloro-4-fluorophenol also finds application in the agrochemical industry, where it is used as a precursor for the development of new pesticides and other crop protection agents. Its chemical properties allow for the creation of compounds with enhanced efficacy and selectivity, contributing to more effective and environmentally friendly agricultural practices.
Used in Chemical Research:
As a versatile organic compound, 2-Chloro-4-fluorophenol is also employed in various research applications. It serves as a model compound for studying the effects of halogen substitution on the reactivity and properties of aromatic systems. Additionally, it can be used to explore the potential of fluorinated compounds in various chemical reactions and processes.
Check Digit Verification of cas no
The CAS Registry Mumber 1996-41-4 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 1,9,9 and 6 respectively; the second part has 2 digits, 4 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 1996-41:
(6*1)+(5*9)+(4*9)+(3*6)+(2*4)+(1*1)=114
114 % 10 = 4
So 1996-41-4 is a valid CAS Registry Number.
InChI:InChI=1/C6H4F2S/c7-4-1-2-6(9)5(8)3-4/h1-3,9H
1996-41-4Relevant articles and documents
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Srivastava,K.C.
, p. 583 - 584 (1964)
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In Situ Formed IIII-Based Reagent for the Electrophilic ortho-Chlorination of Phenols and Phenol Ethers: The Use of PIFA-AlCl3 System
Nahide, Pradip D.,Ramadoss, Velayudham,Juárez-Ornelas, Kevin A.,Satkar, Yuvraj,Ortiz-Alvarado, Rafel,Cervera-Villanueva, Juan M. J.,Alonso-Castro, ángel J.,Zapata-Morales, Juan R.,Ramírez-Morales, Marco A.,Ruiz-Padilla, Alan J.,Deveze-álvarez, Martha A.,Solorio-Alvarado, César R.
, p. 485 - 493 (2018/02/09)
A new and in situ formed reagent generated by mixing PIFA {bis[(trifluoroacetoxy)iodobenzene]} and AlCl3 was introduced in the organic synthesis for the direct and highly regioselective ortho-chlorination of phenols and phenol ethers. An efficient electrophilic chlorination for these electron-rich arenes as well as the scope of the reaction are described herein. An easy, practical, and open-flask reaction allowed us to introduce a chlorine atom, which is a highly important functional group in organic synthesis. The reproducibility of our method has been demonstrated on gram-scale by carrying out the reaction in 6-bromo-2-naphthol. This halogenation reaction also proceeds in excellent conditions by first preparing the iodine(III)-based chlorinating reagent. Our new chlorinating reagent can be stored at least for two weeks at 4 °C without losing its reactivity.
Multisubstituted benzo[b]furans through a copper- and/or palladium-catalyzed assembly and functionalization process
Arcadi, Antonio,Blesi, Federico,Cacchi, Sandro,Fabrizi, Giancarlo,Goggiamani, Antonella,Marinelli, Fabio
, p. 1857 - 1871 (2013/04/10)
Full details as well as the study of the scope, limitations, and further elaboration of a straightforward approach to the synthesis of 2,5,7-trisubstituted benzo[b]furans from 2-bromo- and 2-chloro-6-iodo-4- substituted phenols through a consecutive copper- and/or palladium-catalyzed assembly and functionalization process is described. Functionalization at the C(7) position is carried out by Suzuki-Miyaura cross-coupling, alkynylation, alkenylation, and C-N bond forming reactions. A one-pot protocol for the synthesis of 2,5,7-trisubstituted benzo[b]furans is also reported.
