199997-15-4

Basic information

• Product Name: 10(E)-(Hydroxyimino)-10,11-dihydro-5H-dibenzo[b,f]azepine-5-carboxamide
• Synonyms: BIA-2-024
• CAS NO: 199997-15-4
• Molecular Formula: C₁₅H₁₃N₃O₂
• Molecular Weight: 267.28976
• Mol File: 199997-15-4.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 10(E)-(Hydroxyimino)-10,11-dihydro-5H-dibenzo[b,f]azepine-5-carboxamide(CAS DataBase Reference)
• NIST Chemistry Reference: 10(E)-(Hydroxyimino)-10,11-dihydro-5H-dibenzo[b,f]azepine-5-carboxamide(199997-15-4)
• EPA Substance Registry System: 10(E)-(Hydroxyimino)-10,11-dihydro-5H-dibenzo[b,f]azepine-5-carboxamide(199997-15-4)

Safety Data

• Hazardous Substances Data: 199997-15-4(Hazardous Substances Data)

Upstream product

• 28721-07-5 oxcarbazepine 
• 13031-60-2 methyl γ-aminobutyrate hydrochloride 
• 109-63-7 trifluoroborane diethyl ether 

Relevant articles and documents

Synthesis, anticonvulsant properties and pharmacokinetic profile of novel 10,11-dihydro-10-oxo-5H-dibenz/b,f/azepine-5-carboxamide derivatives

A series of novel derivatives of oxcarbazepine (5), 10,11-dihydro-10-oxo-5H-dibenz/b,f/azepine-5-carboxamide was synthesised and evaluated for their anticonvulsant activity and sodium channel blocking properties. The oxime 8 was found to be the most active compound from this series, displaying greater potency than its geometric isomer 9 and exhibiting also the highest protective index value. Importantly, the metabolic profile of 8 differs from the already established dibenz/b,f/azepine-5-carboxamide drugs such as 1 and 5 which undergo rapid and complete conversion in vivo to several biologically active metabolites. In contrast 8 is metabolised to only a very minor extent leading to the conclusion that the observed anti-convulsant effect is solely attributable to 8. It is concluded that 8 may be as effective as 1 and 5 at controlling seizures and that the low toxicity and consequently high protective index should provide the compound with an improved side-effect profile.

Derivatives of 10,11-dihydro-10-oxo-5h-dibenz/b,f/azepine-5-carboxamide

Compounds of general formula I are described as is a process for their preparation which consists of reacting a compound of formula II with hydroxylamine or its derivatives of formula III H2NOR2The compounds cited in the present inve