20029-52-1Relevant articles and documents
Preparation method of 4-cyclohexylbenzoic acid
-
Paragraph 0013-0015, (2022/01/12)
The invention relates to the technical field of medicine preparation, in particular to a preparation method of 4-cyclohexylbenzoic acid. The preparation method comprises the following steps: 1) preparing a Grignard reagent from 1-bromo-4-cyclohexylbenzene; 2) subjecting the Grignard reagent to reacting with carbon dioxide in an organic solvent; and 3) carrying out acidifying to obtain the 4-cyclohexylbenzoic acid. According to the preparation method of the 4-cyclohexylbenzoic acid, the raw materials are easy to obtain, cost is low, a process is stable, and the prepared 4-cyclohexylbenzoic acid is high in chemical purity; and the conditions of heating, usage of magnesium powder and the like are creatively designed, a small amount of bromocyclohexyl benzene is firstly added for initiation, and then residual bromobenzene is added under the condition of heating, so the preparation of the Grignard reagent of 1-bromo-4-cyclohexylbenzene is realized, the technical defect that an expensive catalyst or an expensive ligand needs to be adopted for preparing 4-cyclohexylbenzoic acid in the prior art is overcome, and remarkable progress is achieved.
Copper catalyzed oxygen assisted C(CNOH)-C(alkyl) bond cleavage: A facile conversion of aryl/aralkyl/vinyl ketones to aromatic acids
Sathyanarayana, Pochampalli,Ravi, Owk,Muktapuram, Prathap Reddy,Bathula, Surendar Reddy
supporting information, p. 9681 - 9685 (2015/09/28)
A novel copper-catalyzed aerobic oxidative C(NOH)-C(alkyl) bond cleavage reaction of aryl/aralkyl/vinyl ketones for the synthesis of aromatic/acrylic acids is described. A series of ketones having aryl/aralkyl/vinyl at the one end and methyl to any higher alkyl at the other end can be selectively cleaved and converted into the corresponding acids via oxime intermediates.
Ruthenium-catalyzed para-selective oxidative cross-coupling of arenes and cycloalkanes
Guo, Xiangyu,Li, Chao-Jun
supporting information; experimental part, p. 4977 - 4979 (2011/11/12)
A novel, direct para-selective oxidative cross-coupling of benzene derivatives with cycloalkanes catalyzed by ruthenium was developed. A wide range of arenes bearing electron-withdrawing substituents was functionalized directly with simple cycloalkanes with high para-selectivity; arenes with electron-donating groups were mainly para-functionalized. Benzoic acid can be used directly.