20034-00-8

Basic information

• Product Name: 1H-Benzimidazole-2-methanol,5-nitro-(9CI)
• Synonyms: 1H-Benzimidazole-2-methanol,5-nitro-(9CI);1H-BenziMidazole-2-Methanol, 6-nitro-;5-Nitro-1H-benziMidazole-2-Methanol;5-Nitro-2-benzimidazolemethanol;(5-Nitrobenzimidazol-2-yl)methanol;(5-Nitro-1H-1,3-benzodiazol-2-yl)methanol
• CAS NO: 20034-00-8
• Molecular Formula: C₈H₇N₃O₃
• Molecular Weight: 193.15948
• Product Categories: BENZIMIDAZOLE
• Mol File: 20034-00-8.mol
• Article Data: 7

Chemical Properties

• Appearance: /
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 1H-Benzimidazole-2-methanol,5-nitro-(9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Benzimidazole-2-methanol,5-nitro-(9CI)(20034-00-8)
• EPA Substance Registry System: 1H-Benzimidazole-2-methanol,5-nitro-(9CI)(20034-00-8)

Safety Data

• Hazardous Substances Data: 20034-00-8(Hazardous Substances Data)

Usage

General Description

1H-Benzimidazole-2-methanol,5-nitro-(9CI) is a chemical compound with the molecular formula C8H6N3O3. It is a derivative of benzimidazole, which is a bicyclic aromatic heterocycle. The compound contains a nitro group, which is a functional group consisting of a nitrogen atom bonded to two oxygen atoms. Nitro compounds are known for their involvement in various biological processes and have potential applications in pharmaceutical and agricultural industries. This specific compound, 1H-Benzimidazole-2-methanol,5-nitro-(9CI), may have medicinal properties and could be used in the development of drugs targeting specific biological processes or pathways. Its unique structure and properties make it an interesting molecule for further research and potential applications in the field of chemistry and medicine.

Upstream product

• 99-56-9 4-Nitrophenylene-1,2-diamine 
• 79-14-1 glycolic Acid 

Downstream Products

• 1357162-40-3 C₂₀H₁₇N₃O₅ 
• 1357162-31-2 C₂₀H₁₇N₃O₅ 
• 14625-39-9 2-(chloromethyl)-5-nitro-1H-benzo[d]imidazole 

Relevant articles and documents

Sustainable Synthesis of 2-Hydroxymethylbenzimidazoles using D-Fructose as a C2 Synthon

D-fructose, a biomass-derived carbohydrate has been identified as an environmentally benign C2 synthon in the preparation of synthetically useful 2-hydroxymethylbenzimidazole derivatives by coupling with 1,2-phenylenediamines. Proof of concept was established by synthesizing 23 examples using BF3.OEt2 (20 mol%), TBHP (5.5 M, decane) (1.0 equiv.) in CH3CN at 90 °C for 1 h. The pivotal features of this method include metal-free conditions, short time, good functional group tolerance, gram scale feasibility and the synthesis of benzimidazole fused 1,4-oxazine. Control studies with conventional C2 synthons did not produce the desired product, thus suggesting a new reaction pathway from D-fructose.

Efficient Synthesis and Biological Activity of Novel Indole Derivatives as VEGFR-2 Tyrosine Kinase Inhibitors

A series of novel indole derivatives were synthesized as potent inhibitors for the vascular endothelial growth factor receptor 2 (VEGFR-2) tyrosine kinase. Among those, compound 10b demonstrated the highest growth inhibition rate of 66.7% against the VEGFR-2 tyrosine kinase at 10 μM which indicates that indole-benzothiazole might be the favorable structure. The binding mode of compound 10b with VEGFR-2 tyrosine kinase was evaluated by molecular docking.

Cytotoxicity of substituted benzimidazolyl curcumin mimics against multi-drug resistance cancer cell

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