200420-11-7

Basic information

• Product Name: (2R,3S)-N-(p-toluenesulphonyl)-3-amino-4-cyclohexyl-2-hydroxybutyrate
• Synonyms: (2R,3S)-N-(p-toluenesulphonyl)-3-amino-4-cyclohexyl-2-hydroxybutyrate
• CAS NO: 200420-11-7
• Molecular Weight: 383.509
• Mol File: 200420-11-7.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: (2R,3S)-N-(p-toluenesulphonyl)-3-amino-4-cyclohexyl-2-hydroxybutyrate(CAS DataBase Reference)
• NIST Chemistry Reference: (2R,3S)-N-(p-toluenesulphonyl)-3-amino-4-cyclohexyl-2-hydroxybutyrate(200420-11-7)
• EPA Substance Registry System: (2R,3S)-N-(p-toluenesulphonyl)-3-amino-4-cyclohexyl-2-hydroxybutyrate(200420-11-7)

Safety Data

• Hazardous Substances Data: 200420-11-7(Hazardous Substances Data)

Upstream product

• 162601-64-1 (2R,3S)-2-hydroxy-3-(tosylamino)butano-4-lactone 
• 652976-66-4 N-((R)-2,5-Dioxo-tetrahydro-furan-3-yl)-4-methyl-benzenesulfonamide 
• 162518-06-1 (R)-4-methyl-N-(5-oxotetrahydrofuran-3-yl)benzenesulfonamide 
• 105198-42-3 ethyl (2E)-4-cyclohexyl-2-butenoate 
• 127-65-1 chloroamine-T 
• 162518-07-2 ethyl (2R,3R)-3-<(N-tosyl)amino>-2-hydroxy-4-iodobutyrate 

Downstream Products

• 203176-14-1 ethyl (2R,3S)-2,3-(N,O-isopropylidene)-3-amino-4-cyclohexyl-2-hydroxybutyrate 
• 185015-78-5 (2R,3S)-4-Cyclohexyl-2-hydroxy-3-(toluene-4-sulfonylamino)-butyric acid 

Relevant articles and documents

Practical synthesis of Abbott amino-diol: A core unit of the potent renin inhibitor Zankiren

Abbott amino-diol (2S,3R,4S)-2-amino-1-cyclohexyl-6-methyl heptane-3,4- diol 1, a main structural constituent of the orally active renin inhibitor Zankiren has been synthesized using Sharpless asymmetric aminohydroxylation as the key step.

A short and efficient enantioselective synthesis of cyclohexylnorstatine, a key component of a renin inhibitor

A catalytic asymmetric synthesis of ethyl (2R,35)-N-(p- toluenesulfonyl)-3-amino-4-cyclohexyl-2-hydroxybutyrate 7 in 96% ee from cheaply available cyclohexanone is described employing Sharpless asymmetric aminohydroxylation as the key step.