200420-37-7Relevant articles and documents
Total synthesis of (-)-verrucarol, a component of naturally occurring verrucarin A
Ishihara, Jun,Nonaka, Rie,Terasawa, Yuki,Shiraki, Ryota,Yabu, Kazuo,Kataoka, Hiromi,Ochiai, Yuichi,Tadano, Kin-Ichi
, p. 8311 - 8314 (1997)
Total synthesis of (-)-verrucarol (1) was achieved starting from D- glucose-derived bicyclic lactone 4 through 1) a stereoselective asymmetric quaternization of the α-carbon of the lactone, 2) Diechmann cyclization for access to the C-ring equivalent, 3) a skeletal rearrangement for the trichothecene ring system, and 4) the final stereoselective epoxidation of an exo-methylene group.
