20051-06-3

Basic information

• Product Name: METHYL (4-ACETYLPHENYL)ACETATE
• Synonyms: METHYL (4-ACETYLPHENYL)ACETATE;METHYL P-ACETYLPHENYLACETATE;Methyl 2-(4-acetylphenyl)acetate
• CAS NO: 20051-06-3
• Molecular Formula: C₁₁H₁₂O₃
• Molecular Weight: 192.21
• Mol File: 20051-06-3.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 300.3°C at 760 mmHg
• Flash Point: 130.6°C
• Appearance: /
• Density: 1.106g/cm³
• Vapor Pressure: 0.00113mmHg at 25°C
• Refractive Index: 1.513
• CAS DataBase Reference: METHYL (4-ACETYLPHENYL)ACETATE(CAS DataBase Reference)
• NIST Chemistry Reference: METHYL (4-ACETYLPHENYL)ACETATE(20051-06-3)
• EPA Substance Registry System: METHYL (4-ACETYLPHENYL)ACETATE(20051-06-3)

Safety Data

• Hazardous Substances Data: 20051-06-3(Hazardous Substances Data)

Usage

Synthesis Reference(s)

Tetrahedron Letters, 42, p. 265, 2001 DOI: 10.1016/S0040-4039(00)01935-3

InChI:InChI=1/C11H12O3/c1-8(12)10-5-3-9(4-6-10)7-11(13)14-2/h3-6H,7H2,1-2H3

Upstream product

• 41841-16-1 (4-bromo-phenyl)-acetic acid methyl ester 
• 431-03-8 dimethylglyoxal 
• 1878-68-8 2-(4-bromophenyl)-acetic acid 
• 97674-02-7 tributyl(1-ethoxyvinyl)stannane 
• 99-90-1 para-bromoacetophenone 
• 96-34-4 methyl chloroacetate 
• 201230-82-2 carbon monoxide 
• 594-27-4 tetramethylstannane 
• 147283-85-0 (4-Trifluoromethanesulfonyloxy-phenyl)-acetic acid methyl ester 
• 75-36-5 acetyl chloride 
• 101-41-7 benzeneacetic acid methyl ester 

Downstream Products

• 7398-47-2 methyl 2-(4-(1-hydroxyethyl)phenyl)acetate 
• 100863-78-3 [4-(1-isopropoxy-ethyl)-phenyl]-acetic acid methyl ester 
• 1032077-66-9 methyl 2-(4-acetylphenyl)-2-bromoacetate 
• 84325-98-4 p-Methoxycarbonylmethylphenylacetyl bromide 
• 46122-65-0 4-vinylbenzeneacetic acid 
• 62667-41-8 p-Vinylphenylperessigsaeure-tert.-butylester 
• 15824-17-6 4-phenethylstyrene 
• 84326-05-6 [4-(6-Nitro-2-oxo-2H-benzo[1,4]oxazin-3-yl)-phenyl]-acetic acid methyl ester 
• 84326-06-7 [4-(8-Chloro-2-oxo-2H-benzo[1,4]oxazin-3-yl)-phenyl]-acetic acid methyl ester 
• 84326-03-4 [4-(6-Chloro-2-oxo-2H-benzo[1,4]oxazin-3-yl)-phenyl]-acetic acid methyl ester 
• 84326-07-8 Methyl 4-(6,8-dimethyl-2H-1,4-benzoxazin-2-one-3-yl) phenyl acetate 
• 84326-04-5 [4-(6-Methyl-2-oxo-2H-benzo[1,4]oxazin-3-yl)-phenyl]-acetic acid methyl ester 
• 84326-02-3 [4-(2-Oxo-2H-benzo[1,4]oxazin-3-yl)-phenyl]-acetic acid methyl ester 
• 84326-00-1 Ethyl p-methoxycarbonylmethylphenylglyoxylate 

Relevant articles and documents

Metal-Free Photoinduced Transformation of Aryl Halides and Diketones into Aryl Ketones

The acylation of aryl halides to prepare aryl ketones without metal catalyst represents an important yet challenging topic towards more sustainable ketone synthesis. Herein, we describe a simple and efficient metal-free protocol for the acylation of aryl halides with diketone under the irradiation of light utilizing N-methylpiperidine as base under an air atmosphere. This reaction can tolerate a wide range of functional groups and the corresponding ketones can be obtained in modest to good yields.

Ni-catalyzed activation of α-chloroesters: a simple method for the synthesis of α-arylesters and β-hydroxyesters

Coupling reactions of α-chloroesters with aryl halides (α-arylation) or carbonyl compounds (Reformatsky) using nickel catalyst allow, under mild conditions, the preparation of various functionalized aryl propionic acid derivatives or β-hydroxyesters. In the synthesis of aryl propionic acid derivatives, the process is efficient with aryl halides bearing either electron-withdrawing or electron-donating groups.