20053-33-2

Basic information

• Product Name: 1/C8H10N2O/c1-11-8-4-2-7(3-5-8)6-10-9/h2-6H,9H2,1H3/b10-6
• CAS NO: 20053-33-2
• Molecular Formula: C₈H₁₀N₂O
• Molecular Weight: 294.224
• Mol File: 20053-33-2.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 1/C8H10N2O/c1-11-8-4-2-7(3-5-8)6-10-9/h2-6H,9H2,1H3/b10-6(CAS DataBase Reference)
• NIST Chemistry Reference: 1/C8H10N2O/c1-11-8-4-2-7(3-5-8)6-10-9/h2-6H,9H2,1H3/b10-6(20053-33-2)
• EPA Substance Registry System: 1/C8H10N2O/c1-11-8-4-2-7(3-5-8)6-10-9/h2-6H,9H2,1H3/b10-6(20053-33-2)

Safety Data

• Hazardous Substances Data: 20053-33-2(Hazardous Substances Data)

Upstream product

• 123-54-6 acetylacetone 
• 97-02-9 2,4-Dinitroanilin 
• 345-12-0 2,4-dinitrophenyldiazonium tetrafluoroborate 
• 1474-32-4 3-(triphenylphosphoranylidene)pentane-2,4-dione 
• 106104-32-9 2-(triphenylarsoranylidene)-2,4-pentanedione 

Relevant articles and documents

Structure-Based Rational Design of Novel Inhibitors Against Fructose-1,6-Bisphosphate Aldolase from Candida albicans

Class II fructose-1,6-bisphosphate aldolases (FBA-II) are attractive new targets for the discovery of drugs to combat invasive fungal infection, because they are absent in animals and higher plants. Although several FBA-II inhibitors have been reported, none of these inhibitors exhibit antifungal effect so far. In this study, several novel inhibitors of FBA-II from C. albicans (Ca-FBA-II) with potent antifungal effects were rationally designed by jointly using a specific protocols of molecular docking-based virtual screening, accurate binding-conformation evaluation strategy, synthesis and enzymatic assays. The enzymatic assays reveal that the compounds 3c, 3e-g, 3j and 3k exhibit high inhibitory activity against Ca-FBA-II (IC50 50 value of 2.7 μM. Importantly, the compounds 3f, 3g, and 3l possess not only high inhibitions against Ca-FBA-II, but also moderate antifungal activities against C. glabrata (MIC80 = 4-64 μg/mL). The compounds 3g, 3l, and 3k in combination with fluconazole (8 μg/mL) displayed significantly synergistic antifungal activities (MIC80 0.0625 μg/mL) against resistant Candida strains, which are resistant to azoles drugs. The probable binding modes between 3g and the active site of Ca-FBA-II have been proposed by using the DOX (docking, ONIOM, and XO) strategy. To our knowledge, no FBA-II inhibitors with antifungal activities against wild type and resistant strains from Candida were reported previously. The positive results suggest that the strategy adopted in this study are a promising method for the discovery of novel drugs against azole-resistant fungal pathogens in the future.

HYDRAZONES FROM YLIDES AND DIAZONIUM SALTS: A CONVENIENT SPOT TEST FOR STABILIZED YLIDES OF PHOSPHORUS, ARSENIC, AND SULFUR

The reactions of a series of stabilized ylides of phosphorus, arsenic and sulfur with 2,4-dinitrobenzenediazonium tetrafluoroborate are described.The reaction courses, leading either to azo-onium salts (II), azo-onium ylides (III), formazanes (IV) or hydr