200626-06-8

Basic information

• Product Name: N-Butyl-4,4',4''-trimethoxytritylamine
• Synonyms: N-Butyl-4,4',4''-trimethoxytritylamine
• CAS NO: 200626-06-8
• Molecular Weight: 405.537
• Mol File: 200626-06-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: N-Butyl-4,4',4''-trimethoxytritylamine(CAS DataBase Reference)
• NIST Chemistry Reference: N-Butyl-4,4',4''-trimethoxytritylamine(200626-06-8)
• EPA Substance Registry System: N-Butyl-4,4',4''-trimethoxytritylamine(200626-06-8)

Safety Data

• Hazardous Substances Data: 200626-06-8(Hazardous Substances Data)

Upstream product

• 437-30-9 4,4',4-trimethoxytrityl tetrafluoroborate 
• 109-73-9 N-butylamine 
• 109-65-9 1-bromo-butane 
• 154776-46-2 4,4',4-trimethoxytritylamine 

Downstream Products

• 3010-81-9 tris(4-methoxyphenyl)methanol 
• 14999-64-5 n-butylammonium perchlorate 
• 3858-78-4 n-butylamine hydrochloride 

Relevant articles and documents

4,4′-Dimethoxytrityl and 4,4′,4″-trimethoxytrityl as protecting groups for amino functions; selectivity for primary amino groups and application in 15N-labelling

4,4′-Dimethoxytrityl tetrafluoroborate (DMT+ BF4-) and 4,4′,4″-trimethoxytrityl tetrafluoroborate (TMT+ BF4-) are useful reagents for protecting primary and some secondary amines. Protected amines are obtained either by reaction of DMT+ BF4- or TMT+ BF4- with the amine or by alkylating DMT- or TMT-amine (available from DMT+ BF4- and TMT+ BF4- by treatment with ammonia). Alkylation of DMT- or TMT-amine stops after monoalkylation. Deprotection of the alkylated DMT- and TMT-amine is achieved by treatment with an acid of appropriate molarity (e.g. 0.1 M HCl in 1:1 tetrahydrofuran-water for TMT-amines). The value of the methodology described is illustrated by a synthesis of (15NH2) adenosine. X-Ray molecular structures of one DMT and two TMT derivatives are reported.