20064-19-1

Basic information

• Product Name: PROPIONYL-L-CARNITINE HYDROCHLORIDE
• Synonyms: PROPIONYL-L-CARNITINE CHLORIDE;PROPIONYL L-CARNITINE HCL;PROPIONYL-LEVO-CARNITINE HYDROCHLORIDE;(R)-Propionyl Carnitine;(2R)-3-Carboxy-N,N,N-trimethyl-2-(1-oxopropoxy)-1-propanaminium Inner Salt;L-Carnitine Propionyl Ester;Levocarnitine Propil;L-Propionylcarnitine
• CAS NO: 20064-19-1
• Molecular Formula: C₁₀H₁₉NO₄
• Molecular Weight: 253.72
• Product Categories: Mixed Fatty Acids;Amino Acids & Derivatives;Intermediates & Fine Chemicals;Pharmaceuticals
• Mol File: 20064-19-1.mol
• Article Data: 0

Chemical Properties

• Boiling Point: °Cat760mmHg
• Flash Point: °C
• Appearance: /
• Density: g/cm³
• Storage Temp.: 2-8°C
• CAS DataBase Reference: PROPIONYL-L-CARNITINE HYDROCHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: PROPIONYL-L-CARNITINE HYDROCHLORIDE(20064-19-1)
• EPA Substance Registry System: PROPIONYL-L-CARNITINE HYDROCHLORIDE(20064-19-1)

Safety Data

• Hazardous Substances Data: 20064-19-1(Hazardous Substances Data)

Usage

Description

Propionyl-L-carnitine (PLC), a natural odd-carbon-number ester of L-carnitine, is an endogenous compound found in humans and animals. It serves as a carrier of long-chain acyl groups from activated fatty acids across the inner mitochondrial membrane into the mitochondrial matrix, where they undergo β-oxidation to acetyl CoA, generating usable energy through the citric acid cycle.

Uses

Used in Cardiology:
Propionyl-L-carnitine is used as a therapeutic agent for improving heart mechanical recovery and other metabolic parameters after ischemia-reperfusion. This application is particularly relevant in the context of cardiovascular health and recovery from heart-related conditions.
Used in Nutritional Science:
Propionyl-L-carnitine is used as a supplement in the drinking water of rats, indicating its potential use in the field of nutritional science for enhancing overall health and well-being in animals. This application may have implications for human nutrition as well.
Used in Analytical Chemistry:
In the field of analytical chemistry, Propionyl-L-carnitine serves as a standard in liquid chromatography-tandem mass spectrometry (LC-MS/MS). This application highlights its importance in ensuring accurate and reliable measurements in various chemical analyses.

Biochem/physiol Actions

Propionyl-L-carnitine (PLC) plays a key role in lipid and carbohydrate metabolism. It provides substrates to the ischemic muscle for energy production and ATP generation. PLC has the potential to treat severe peripheral arterial disease and chronic heart failure. It is present in high abundance in the urine of patients with methylmalonyl-CoA mutase (MUT) deficiency, together with methylmalonic acid. MUT is a mitochondrial enzyme that catalyzes the isomerization of methylmalonyl-CoA to succinyl-CoA.

InChI:InChI=1/C10H19NO4/c1-5-10(14)15-8(6-9(12)13)7-11(2,3)4/h8H,5-7H2,1-4H3/t8-/m1/s1