200803-30-1

Basic information

• Product Name: Benzenepropanamide, N-[(1S)-1-phenylethyl]-
• CAS NO: 200803-30-1
• Molecular Formula: C17H19NO
• Molecular Weight: 253.344
• Mol File: 200803-30-1.mol
• Article Data: 14

Chemical Properties

• CAS DataBase Reference: Benzenepropanamide, N-[(1S)-1-phenylethyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzenepropanamide, N-[(1S)-1-phenylethyl]-(200803-30-1)
• EPA Substance Registry System: Benzenepropanamide, N-[(1S)-1-phenylethyl]-(200803-30-1)

Safety Data

• Hazardous Substances Data: 200803-30-1(Hazardous Substances Data)

Upstream product

• 103-25-3 3-phenylpropanoic acid methyl ester 
• 618-36-0 rac-methylbenzylamine 
• 501-52-0 3-Phenylpropionic acid 
• 2627-86-3 (S)-1-phenyl-ethylamine 
• 109318-10-7 2,5-dioxopyrrolidin-1-yl 3-phenylpropanoate 
• 104-53-0 3-phenyl-propionaldehyde 
• 645-45-4 hydrocinnamic acid chloride 
• 115914-08-4 (S)-N-(1-phenylethyl)prop-2-en-1-amine 
• 71-23-8 propan-1-ol 

Downstream Products

• 200803-59-4 (R)-3,4-Diphenyl-butyric acid butyl ester 
• 6995-48-8 (R)-3,4-diphenyl butanoic acid 
• 20453-83-2 4,5-diphenyldihydrofuran-2(3H)-one 
• 200803-34-5 (R)-3,4-Diphenyl-N-((S)-1-phenyl-ethyl)-butyramide 

Relevant articles and documents

Me2NSO2Cl and N,N-dimethylamines; a novel and efficient agent for esterification, amidation between carboxylic acids, and equimolar amounts of alcohols and amines

Various carboxylic esters or amides were prepared in good to excellent yields between carboxylic acids and equimolar amounts of alcohols or amines under very mild conditions using dimethylsulfamoyl chloride (Me2NSO2Cl) combined with N,N-dimethylamines. The choice of the sulfamoyl chloride and the amine is crucial for the reactions.

Amides in one pot from Carboxylic Acids and Amines via Sulfinylamides

An efficient method has been developed for the direct amidification of carboxylic acids via sulfinylamides preformed in situ by the reaction of pure amines with prop-2- ene-1-sulfinyl chloride. The method can be applied to aliphatic acids, including pivalic acid, aromatic acids, and primary and secondary amines. It is compatible with acids bearing unprotected alcohol, phenol, and ketone moieties and applicable to the synthesis of peptides. It does not induce their a-epimerization.

Pseudomonas stutzeri lipase: A useful biocatalyst for aminolysis reactions

The use of Pseudomonas stutzeri lipase (PSL) as a biocatalyst for aminolysis reactions with bulky substrates has been investigated. PSL compared favorably to Novozym 435 (immobilized Candida antarctica lipase B, NOV435) in the aminolysis of various bulky methyl esters and amines. While NOV435 demonstrated a higher rate of aminolysis with methyl 2-phenylpropionic acid as the acyl donor, PSL outperformed NOV435 with secondary amines as the nucleophile. Methanol inhibition and a low affinity for bulky acyl donors were found to be the two main reasons for relatively low rates in the PSL-catalyzed aminolysis reactions. It was demonstrated that the use of molsieve 4A had a significant effect on the aminolysis rate and amide yield, since it enabled the effective removal of the inhibiting methanol from the reaction mixture.