200956-99-6Relevant articles and documents
1,4-THIAZANES AS CONFORMATIONALLY-RESTRICTED ANALOGS OF THE PEPTIDO-LEUKOTRIENES
Ennis, Michael D.,Baze, Mark E.
, p. 6533 - 6536 (1988)
A new class of leukotriene antagonists is proposed which represent rigidified approximations of the solution conformation of the peptido-leukotrienes.A representative member of this class has been synthesized and shown to elicit response in the guinea pig ileum assay.
LIPID COMPOUNDS AND COMPOSITIONS AND THEIR OPTHALMIC USE
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Page/Page column 65; 66, (2017/07/23)
The invention relates to lipid compounds of formula (I) and their pharmaceutically acceptable salts for the prevention and/or treatment of ophthalmic disorders such as retinal degenerative disorders and ocular inflammatory diseases: (I) (wherein R1 is either a C9 to C22 alkyl group, or a C9 to C22 alkenyl group having from 1 to 6 double bonds; R2 is selected from the group consisting of a halogen atom, a hydroxy group, an alkyl group, an alkoxy group, an alkylthio group, a carboxy group, an acyl group, an amino group, and an alkylamino group; R3 is a hydrogen atom, or a group R2; R4 is a carboxylic acid or a derivative thereof; and X is methylene (-CH2-), or an oxygen or sulfur atom).
Use of cis-Epoxyeicosantrienoic acids and inhibitors of soluble epoxide hydrolase to reduce pulmonary infiltration by neutrophils
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Page/Page column 12, (2008/06/13)
It has now been discovered that inhibitors of soluble epoxide hydrolase (“sEH”) are useful in reducing the severity of or inhibiting the progression of obstructive pulmonary diseases, restrictive airway diseases, and asthma. Administering a cis-epoxyeicosantrienoic acid (“EET”) in addition to the inhibitor is at least additive, and may be synergistic, in reducing or inhibiting these conditions and diseases, as measured by reduced numbers of neutrophils present in the lung. The inhibitor of sEH may be a nucleic acid, such as a small interfering RNA.
