20107-46-4

Basic information

• Product Name: 1-(2,6-Dimethoxyphenyl)-3-(2-hydroxy-5,6-dimethoxyphenyl)-2refH-propen-⁽¹⁾-on-⁽³⁾-ol-(1trans)
• Synonyms: 1-(2,6-Dimethoxyphenyl)-3-(2-hydroxy-5,6-dimethoxyphenyl)-2refH-propen-⁽¹⁾-on-⁽³⁾-ol-(1trans)
• CAS NO: 20107-46-4
• Molecular Weight: 360.364
• Mol File: 20107-46-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 1-(2,6-Dimethoxyphenyl)-3-(2-hydroxy-5,6-dimethoxyphenyl)-2refH-propen-⁽¹⁾-on-⁽³⁾-ol-(1trans)(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(2,6-Dimethoxyphenyl)-3-(2-hydroxy-5,6-dimethoxyphenyl)-2refH-propen-⁽¹⁾-on-⁽³⁾-ol-(1trans)(20107-46-4)
• EPA Substance Registry System: 1-(2,6-Dimethoxyphenyl)-3-(2-hydroxy-5,6-dimethoxyphenyl)-2refH-propen-⁽¹⁾-on-⁽³⁾-ol-(1trans)(20107-46-4)

Safety Data

• Hazardous Substances Data: 20107-46-4(Hazardous Substances Data)

Upstream product

• 33539-20-7 6-methoxy-2,5-dihydroxyacetophenone 
• 703-23-1 2'-hydroxy-6'-methoxyacetophenone 
• 22248-13-1 1-(6-hydroxy-2,3-dimethoxyphenyl)ethan-1-one 
• 1989-53-3 2,6-dimethoxybenzoyl chloride 

Downstream Products

• 14813-19-5 2-(2,6-dimethoxyphenyl)-5.6-dimethoxy-4H-1-benzopyran-4-one 

Relevant articles and documents

Synthesis and cancer chemopreventive activity of zapotin, a natural product from Casimiroa edulis

An efficient method has been developed to synthesize zapotin (5,6,2′,6′-tetramethoxyflavone), a component of the edible fruit Casimiroa edulis, on a multigram scale. The synthesis utilizes a regioselective C-acylation of a dilithium dianion derived from a substituted o-hydroxyactophenone to afford a β-diketone intermediate that can be cyclized to zapotin in good overall yield, thus avoiding the inefficient Baker-Venkataraman rearrangement pathway. Zapotin was found to induce both cell differentiation and apoptosis with cultured human promyelocytic leukemia cells (HL-60 cells). In addition, the compound inhibits 12-O-tetrade-canoylphorbol 13-acetate (TPA)-induced ornithine decarboxylase (ODC) activity with human bladder carcinoma cells (T24 cells), and TPA-induced nuclear factor-kappa B (NF-κB) activity with human hepatocellular liver carcinoma cells (HepG2 cells). These data suggest that zapotin merits further investigation as a potential cancer chemopreventive agent.