20133-19-1

Basic information

• Product Name: 1-(3,4-Dimethoxyphenyl)-1,2-propanediol
• Synonyms: 1-(3,4-Dimethoxyphenyl)-1,2-propanediol;1-(3,4-Dimethoxyphenyl)propane-1,2-diol;Methyl isoeugenol glycol
• CAS NO: 20133-19-1
• Molecular Formula: C₁₁H₁₆O₄
• Molecular Weight: 212.2423
• Mol File: 20133-19-1.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 382.2°Cat760mmHg
• Flash Point: 184.9°C
• Appearance: /
• Density: 1.162g/cm³
• Vapor Pressure: 1.6E-06mmHg at 25°C
• Refractive Index: 1.535
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 1-(3,4-Dimethoxyphenyl)-1,2-propanediol(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(3,4-Dimethoxyphenyl)-1,2-propanediol(20133-19-1)
• EPA Substance Registry System: 1-(3,4-Dimethoxyphenyl)-1,2-propanediol(20133-19-1)

Safety Data

• Hazardous Substances Data: 20133-19-1(Hazardous Substances Data)

Usage

General Description

1-(3,4-Dimethoxyphenyl)-1,2-propanediol, also known as DMPD, is a chemical compound with a molecular formula C11H16O4. It is a type of diol, which means it has two hydroxyl (-OH) groups. 1-(3,4-Dimethoxyphenyl)-1,2-propanediol is composed of a benzene ring with two methoxy (-OCH3) groups attached to it, and a 1,2-propanediol backbone. DMPD is commonly used in the synthesis of pharmaceuticals and as a reagent in organic chemistry reactions. It has also been studied for its potential antioxidant and anti-inflammatory properties. Additionally, DMPD has been investigated for its ability to inhibit the growth of certain cancer cells. However, further research is needed to fully understand its potential applications and effects.

InChI:InChI=1/C11H16O4/c1-14-10-4-3-8(5-11(10)15-2)9(6-12)7-13/h3-5,9,12-13H,6-7H2,1-2H3

Upstream product

• 93-16-3 Methylisoeugenol 
• 6379-72-2 1,2-dimethoxy-4-(E)-propenylbenzene 

Downstream Products

• 58045-92-4 1,2-diacetoxy-1-(3,4-dimethoxy-phenyl)-propane 
• 120-14-9 3,4-dimethoxy-benzaldehyde 
• 4732-70-1 3,4-dimethoxyphenylglyoxylic acid 
• 64-19-7 acetic acid 
• 93-07-2 Veratric acid 

Relevant articles and documents

Metabolism of methylisoeugenol in liver microsomes of human, rat, and bovine origin

Methylisoeugenol (1,2-dimethoxy-4-propenylbenzene, 1) is a minor constituent of essential oils, naturally occurring as a mixture of cis/trans isomers. 1 is a U.S. Food and Drug Administration-approved food additive and has been given "Generally Recognized as Safe" status. Previously, metabolism of 1 has been studied in the rat, revealing mainly nontoxic cinnamoyl derivatives as major metabolites. However, data concerning the possible formation of reactive intermediary metabolites are not available to date. In this study, the oxidative metabolism of 1 was studied using liver microsomes of rat [not induced, rat liver microsomes (RLM); Aroclor1254 induced RLM (ARLM)], bovine, and human (pooled from 150 donors) origin. Incubations of these microsomes with 1 provided phase I metabolites that were separated by high-performance liquid chromatography (HPLC) and identified by NMR and UV-visible spectroscopy and/or liquid chromatography-mass spectrometry. Identity was confirmed by comparison with 1H NMR spectra of synthesized reference compounds. Formation of metabolites was quantified by HPLC/UV using dihydromethyleugenol (10) synthesized as the internal standard. From incubations of ARLM with 1, seven metabolites could be detected, with 3′- hydroxymethylisoeugenol (2), isoeugenol and isochavibetol (3 + 4), and 6-hydroxymethylisoeugenol (5) being the main metabolites. Secondary metabolites derived from 1 were identified as the α,β-unsaturated aldehyde 3′-oxomethylisoeugenol (6) and 1′,2′-dihydroxy- dihydromethylisoeugenol (7). We were surprised to find that formation of allylic 6-hydroxymethyleugenol (8) was observed starting at approximately 30 min after the beginning of incubations with ARLM. HLM did not form ring-hydroxylated metabolites but were most active in the formation of 6 and 7. ARLM incubations displayed the highest turnover rate and broadest metabolic pattern, presumably resulting from an increased expression of cytochrome P450 enzymes. In conclusion, we present a virtually complete pattern of nonconjugated microsomal metabolites of 1 comprising reactive metabolites and suggest the formation of reactive intermediates that need more investigation with respect to their possible adverse properties. Copyright

Electron-transfer Processes: Oxidation of α- and β-Alkenylbenzenes by Peroxydisulphate in Acetic Acid

Oxidation of α- and β-unsaturated alkylbenzenes by peroxydisulphate in acetic acid gives side-chain acetoxylation with formation of the corresponding glycol diacetates and compounds (10), respectively.The reaction is catalysed by transition-metal salts, among which cupric acetate gives the best results.Generally, electron-releasing substituents on the benzene ring increase the yield and improve the selectivity.The same substrates are oxidized in water under Ag+ catalysis to the corresponding aldehydes.The different behaviour in the two solvents is ascribed to the difference in reactivity between the primary oxidation products and the starting olefin, whereas the initial oxidation step is suggested to occur in both cases via an electron-transfer process from the olefin to the sulphate radical anion.