201355-36-4Relevant articles and documents
Rational design and synthesis of a novel, selective class of thrombin inhibitors: P1-argininal derivatives incorporating P3-P4 quaternary lactam dipeptide surrogates
Semple, J. Edward,Minami, Nathaniel K.,Tamura, Susan Y.,Brunck, Terence K.,Nutt, Ruth F.,Ripka, William C.
, p. 2421 - 2426 (2007/10/03)
SAR and molecular modeling investigations on the potent and selective thrombin inhibitor 1b (CVS 1578) and related serine protease inhibitors led to the design of series 2a-g, featuring quaternary α-amino-α-benzyl-lactam scaffolds that serve as novel P3-P4 dipeptide mimics. The design, synthesis, and biological activity of these targets an presented.
