201530-44-1

Basic information

• Product Name: (4-(3,5-bis(2-hydroxyphenyl)-1H-1,2,4-triazol-1-yl)phenyl)(4-methylpiperazin-1-yl)methanone
• Synonyms: (4-(3,5-bis(2-hydroxyphenyl)-1H-1,2,4-triazol-1-yl)phenyl)(4-methylpiperazin-1-yl)methanone
• CAS NO: 201530-44-1
• Molecular Weight: 455.516
• Mol File: 201530-44-1.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: (4-(3,5-bis(2-hydroxyphenyl)-1H-1,2,4-triazol-1-yl)phenyl)(4-methylpiperazin-1-yl)methanone(CAS DataBase Reference)
• NIST Chemistry Reference: (4-(3,5-bis(2-hydroxyphenyl)-1H-1,2,4-triazol-1-yl)phenyl)(4-methylpiperazin-1-yl)methanone(201530-44-1)
• EPA Substance Registry System: (4-(3,5-bis(2-hydroxyphenyl)-1H-1,2,4-triazol-1-yl)phenyl)(4-methylpiperazin-1-yl)methanone(201530-44-1)

Safety Data

• Hazardous Substances Data: 201530-44-1(Hazardous Substances Data)

Upstream product

• 109-01-3 1-methyl-piperazine 
• 26189-59-3 1-chloro-1-(dimethylamino)-2-methyl-1-propene 
• 201530-41-8 deferasirox 
• 1218-69-5 2-(2-hydroxyphenyl)-4H-benzo[e][1,3]oxazin-4-one 
• 65-45-2 salicylamide 
• 69-72-7 salicylic acid 

Relevant articles and documents

In vitrostudies of deferasirox derivatives as potential organelle-targeting traceable anti-cancer therapeutics

We report here strategic functionalization of the FDA approved chelator deferasirox (1) in an effort to produce organelle-targeting iron chelators with enhanced activity against A549 lung cancer cells. Derivative 8 was found to have improved antiproliferative activity relative to 1. Fluorescent cell imaging revealed that compound 8 preferentially localises within the lysosome.

Substituted 3,5-diphenyl-1,2,4-triazoles and their use as pharmaceutical metal chelators

The use is described of 3,5-diphenyl-1,2,4-triazoles of the formula I in which R1-R5are as defined in the description. The compounds have useful pharmaceutical properties and are particularly active as iron chelators. They can be used for the treatment of iron overload in warm-blooded animals.