20157-46-4

Basic information

• Product Name: 1H-Pyrazole, 3,5-dimethyl-1-(4-methylphenyl)-
• CAS NO: 20157-46-4
• Molecular Formula: C12H14N2
• Molecular Weight: 186.257
• Mol File: 20157-46-4.mol
• Article Data: 20

Chemical Properties

• CAS DataBase Reference: 1H-Pyrazole, 3,5-dimethyl-1-(4-methylphenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Pyrazole, 3,5-dimethyl-1-(4-methylphenyl)-(20157-46-4)
• EPA Substance Registry System: 1H-Pyrazole, 3,5-dimethyl-1-(4-methylphenyl)-(20157-46-4)

Safety Data

• Hazardous Substances Data: 20157-46-4(Hazardous Substances Data)

Upstream product

• 123-54-6 acetylacetone 
• 539-44-6 N-4-methylphenylhydrazine 
• 106-43-4 para-chlorotoluene 
• 67-51-6 3,5-dimethyl-1H-pyrazole 
• 352-32-9 p-fluorotoluene 
• 637-60-5 p-tolylhydrazine hydrochloride 
• 10199-63-0 1-(3,5-dimethyl-1H-pyrazol-1-yl)ethanone 
• 5720-05-8 4-methylphenylboronic acid 

Downstream Products

• 91768-96-6 3,5-dimethyl-4-thiocyanato-1-(p-tolyl)-1H-pyrazole 
• 108444-21-9 3,5-Dimethyl-1-p-tolyl-1H-pyrazole-4-carboxylic acid 

Relevant articles and documents

Preparation method of pyrazole derivative

The present invention discloses a method for preparing a pyrazole derivative. The method comprises the following steps: the arylhydrazine derivative is mixed with an alkyldione derivative, reaction, to obtain a pyrazole derivative; wherein the structure of the arylhydrazine derivative is as follows: the structure of the alkyldione derivative is as follows: the structure of the pyrazole derivative provided by the present invention is green safe, simple and efficient, mild conditions, no catalyst, low cost, high synthesis efficiency. This method can synthesize a variety of 1,3,4,5-tetra-substituted pyrazole derivatives, and the method can be widely used in the field of organic synthesis.

Visible-light enabled C4-thiocyanation of pyrazoles by graphite-phase carbon nitride (g-C3N4)

Thiocyanation is an important and effective way to form C[sbnd]S bonds in organic synthetic methodology. Especially, thiocyanation of pyrazole attracts the attention of many researchers because sulfur-containing compounds are widely applied in many crucial fields such as organic materials, agrochemistry, nanotechnology, etc. Herein, we described A rapid metal- and additive-free method for C(sp2)-H thiocyanation of pyrazoles under visible light at room temperature by using a sustainable catalyst of graphite-phase carbon nitride (g-C3N4) and a thiocyanating agent of ammonium thiocyanate. The method presents many advantages, such as usage of eco-friendly photoredox catalyst, a wide range of substrates and a good yield of products, etc.

Nucleophilic aromatic substitution of unactivated fluoroarenes enabled by organic photoredox catalysis

Nucleophilic aromatic substitution (SNAr) is a classical reaction with well-known reactivity toward electron-poor fluoroarenes. However, electron-neutral and electron-rich fluoro(hetero)arenes are considerably underrepresented. Herein, we present a method for the nucleophilic defluorination of unactivated fluoroarenes enabled by cation radical-accelerated nucleophilic aromatic substitution. The use of organic photoredox catalysis renders this method operationally simple under mild conditions and is amenable to various nucleophile classes, including azoles, amines, and carboxylic acids. Select fluorinated heterocycles can be functionalized using this method. In addition, the late-stage functionalization of pharmaceuticals is also presented. Computational studies demonstrate that the site selectivity of the reaction is dictated by arene electronics.