20191-74-6

Basic information

• Product Name: 2-Ethyl-5-nitrobenzenamine ,98%
• Synonyms: 2-Ethyl-5-nitrobenzenamine ,98%;2-ethyl-5-nitroaniline;BenzenaMine, 2-ethyl-5-nitro-;2-Ethyl-5-nitro-phenylaMine;4-Nitro-2-amino-1-ethylbenzene;2-Ethyl-5-nitroaniline 2-Ethyl-5-nitrobenzenamine;2-Ethyl-5-nitrobenzenamine 98%
• CAS NO: 20191-74-6
• Molecular Formula: C₈H₁₀N₂O₂
• Molecular Weight: 166.179
• Mol File: 20191-74-6.mol
• Article Data: 14

Chemical Properties

• Melting Point: 63-64℃ (methanol )
• Boiling Point: 335.339 °C at 760 mmHg
• Flash Point: 156.607 °C
• Appearance: /
• Density: 1.218±0.06 g/cm3 (20 ºC 760 Torr)
• Vapor Pressure: 0.000121mmHg at 25°C
• Refractive Index: 1.598
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• PKA: 2.25±0.10(Predicted)
• CAS DataBase Reference: 2-Ethyl-5-nitrobenzenamine ,98%(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Ethyl-5-nitrobenzenamine ,98%(20191-74-6)
• EPA Substance Registry System: 2-Ethyl-5-nitrobenzenamine ,98%(20191-74-6)

Safety Data

• Statements: 20/21/22
• Safety Statements: 36/37
• Hazardous Substances Data: 20191-74-6(Hazardous Substances Data)

Usage

InChI:InChI=1/C8H10N2O2/c1-2-6-3-4-7(10(11)12)5-8(6)9/h3-5H,2,9H2,1H3

Upstream product

• 1204-29-1 1-ethyl-2,4-dinitrobenzene 
• 612-22-6 2-nitro(ethylbenzene) 
• 33098-65-6 2-acetamido-1-ethylbenzene 
• 578-54-1 ortho-ethylaniline 

Downstream Products

• 90005-90-6 2-ethyl-5-nitro-phenol 
• 42782-54-7 3-Chloro-4-ethylnitrobenzene 
• 133053-77-7 2,4-dibromo-6-ethyl-3-nitroaniline 
• 133053-75-5 methyl N-(6-ethyl-3-nitrophenyl)-formimidate 
• 52121-34-3 2-bromo-1-ethyl-4-nitrobenzene 
• 933045-59-1 2-ethyl-5-(thiazol-2-ylamino)phenol 
• 207923-07-7 5-amino-2-ethyl-phenol 
• 52121-36-5 3-bromo-4-ethylphenylamine 
• 52121-38-7 3-bromo-4-ethyl-6-nitroaniline 
• 1028308-26-0 N-(3-Bromo-4-ethyl-phenyl)-2,2,2-trifluoro-acetamide 
• 186666-73-9 (5-Bromo-4-ethyl-2-nitro-phenylamino)-acetic acid ethyl ester 
• 186666-72-8 N-(5-Bromo-4-ethyl-2-nitro-phenyl)-2,2,2-trifluoro-acetamide 
• 1313372-75-6 3?methyl?6?nitro?1H?indazole 
• 635702-60-2 2,3-dimethyl-2H-indazole-6-amine hydrochloride 

Relevant articles and documents

Preparation method of pazopanib intermediate

The invention provides a preparation method of a pazopanib key intermediate 2,3-dimethyl-N-(2-chloropyrimidin-4-yl)-N-methyl-2H-indazole-6-amine. The method comprises the following steps: by taking 6-halogenated-2,3-dimethyl-2H-indazole as a raw material, conducting reacting to obtain N,2,3-trimethyl-2H-indazole-6-amine; and further carrying out a reaction to obtain the 2,3-dimethyl-N-(2-chloropyrimidin-4-yl)-N-methyl-2H-indazole-6-amine. The method has the advantages of short synthesis route, accessible raw materials, low cost, mild reaction conditions, high safety and high yield, and is suitable for industrial mass production.

2,3-dimethyl-6-urea -2H-indazoles and its preparation method and application

The invention discloses a 2, 3-dimethyl-6-urea-2H-indazole compound shown by the following general formula (I), medicinal salt or a solvent compound thereof, wherein Ar is substituted or unsubstituted phenyl or aromatic matrix. The invention also discloses a preparation method and application of the compound. The compound can regulate signal transduction of tyrosine kinase, inhibit bad cellular proliferation, and particularly has obvious curative effect for tumors.

THIENOPYRIMIDINE COMPOUNDS

The present invention relates to the use of novel compounds of Formula I: wherein all variable substituents are defined as described herein, which are SYK inhibitors and are useful for the treatment of auto-immune and inflammatory diseases.