20193-21-9

Basic information

• Product Name: N-BUTYL-N-PROPYLAMINE
• Synonyms: N-(n-Butyl)-n-propylamine;PROPYL-N-BUTYLAMINE;Propyl-1-butanamine, N-;N-Propyl-1-butanamine;Propylbutylamine;1-Butanamine, N-propyl-;Einecs 243-575-5;N-PropylbutylaMine 98%
• CAS NO: 20193-21-9
• Molecular Formula: C₇H₁₇N
• Molecular Weight: 115.22
• EINECS: 243-575-5
• Product Categories: Amines;C7;Nitrogen Compounds
• Mol File: 20193-21-9.mol
• Article Data: 9

Chemical Properties

• Melting Point: -38°C (estimate)
• Boiling Point: 133-134 °C(lit.)
• Flash Point: 77 °F
• Appearance: /
• Density: 0.745 g/mL at 25 °C(lit.)
• Vapor Pressure: 5.71mmHg at 25°C
• Refractive Index: n20/D 1.412(lit.)
• PKA: 11.02±0.19(Predicted)
• CAS DataBase Reference: N-BUTYL-N-PROPYLAMINE(CAS DataBase Reference)
• NIST Chemistry Reference: N-BUTYL-N-PROPYLAMINE(20193-21-9)
• EPA Substance Registry System: N-BUTYL-N-PROPYLAMINE(20193-21-9)

Safety Data

• Hazard Codes: F,C,Xi
• Statements: 11-34
• Safety Statements: 16-26-36/37/39-45
• RIDADR: UN 2733 3/PG 1
• WGK Germany: 3
• HazardClass: IRRITANT, CORROSIVE
• Hazardous Substances Data: 20193-21-9(Hazardous Substances Data)

Usage

General Description

N-propylbutylamine is an aliphatic amine. It is formed when butylamine is heated with 1-propanol in the presence of Raney nickel. Its effect as a pore directing template on the pore size and surface area of microporous mixed metal oxides has been investigated. Some of its physical and thermophysical properties have been reported.

InChI:InChI=1/C7H17N/c1-3-5-7-8-6-4-2/h8H,3-7H2,1-2H3

Upstream product

• 71-23-8 propan-1-ol 
• 109-74-0 propyl cyanide 
• 2955-67-1 N-butylpropionamide 
• 110-91-8 morpholine 
• 130716-87-9 N-butylidenebutylamine 
• 513-81-5 2,3-dimethyl-buta-1,3-diene 
• 64-17-5 ethanol 
• 7707-71-3 butylidene-propyl-amine 
• 30532-99-1 allyl-butyliden-amine 
• 74-85-1 ethene 
• 201230-82-2 carbon monoxide 
• 109-73-9 N-butylamine 
• 107-10-8 propylamine 
• 123-72-8 butyraldehyde 

Downstream Products

• 25413-64-3 N-Nitroso-N-butyl-N-propylamine 
• 7707-71-3 butylidene-propyl-amine 
• 502767-31-9 N₂-butyl-6-chloro-N₄-(3-chloro-4-methoxy-phenyl)-N₂-propyl-[1,3,5]triazine-2,4-diamine 
• 136722-37-7 7-(Butyl-propyl-amino)-1-cyclohexyl-1-hydroxy-1-phenyl-hept-5-yn-2-one 
• 1053256-23-7 (4S,5R,6R)-5-Acetylamino-4-tert-butoxycarbonylamino-6-(butyl-propyl-carbamoyl)-5,6-dihydro-4H-pyran-2-carboxylic acid benzhydryl ester 
• 141328-60-1 N-n-propyl-N-n-butyl 2-phenylacetamide 
• 24551-99-3 N-methyl-N-propylbutylamine 

Relevant articles and documents

Selective one-pot synthesis of asymmetric secondary amines via N-alkylation of nitriles with alcohols

The synthesis of asymmetric secondary amines (ASA) is commonly achieved by N-alkylation of primary amines with alcohols. Here, we investigated the ASA synthesis via the direct amination of alcohols with nitriles, which avoids the synthesis, separation and purification of the primary amines in a first step. Specifically, the ASA synthesis via N-alkylation of butyronitrile (BN) with primary (n-propanol, iso-butanol and n-octanol) and secondary (2‐propanol, 2‐butanol and 2‐octanol) alcohols was studied on SiO2-supported Co, Ni and Ru catalysts. Competitive BN hydrogenation‐condensation reactions formed dibutylamine (the symmetric secondary amine) and tertiary amines as main secondary products. On Co/SiO2, the ASA selectivities for BN/primary alcohol reactions were between 49 and 58% at complete BN conversion, forming dibutylamine and tertiary amines as byproducts. For BN/secondary alcohol reactions, Co/SiO2 formed selectively (ASA + dibutylamine) mixtures containing 78–85% of ASA, thereby showing that the alcohol amination with nitriles is an attractive alternative route for the synthesis of valuable asymmetric secondary amines.

Catalytic hydrogenation of amides to amines under mild conditions

Under (not so much) pressure: A general method for the hydrogenation of tertiary and secondary amides to amines with excellent selectivity using a bimetallic Pd-Re catalyst has been developed. The reaction proceeds under low pressure and comparatively low temperature. This method provides organic chemists with a simple and reliable tool for the synthesis of amines. Copyright

PHOSPHONIUM DIAZA-DIYLIDS AND AZA-YLDIID AS NEW AND EFFICIENT REAGENTS FOR PRIMARY AND SECONDARY AMINES SYNTHESIS

Metallated aminophosphonium ylids, diaza-diylids and aza-yldiid, are investigated as reagents for primary and secondary amines synthesis.