201940-08-1 Usage
Description
tert-Butyl 5-bromoisoindoline-2-carboxylate is an organic compound that serves as a key intermediate in the synthesis of various pharmaceutical agents. It is characterized by its unique molecular structure, which includes a tert-butyl group, a bromo substituent, and an isoindoline-2-carboxylate moiety. tert-Butyl 5-bromoisoindoline-2-carboxylate plays a crucial role in the development of new drugs with improved therapeutic properties.
Uses
Used in Pharmaceutical Industry:
tert-Butyl 5-bromoisoindoline-2-carboxylate is used as a synthetic intermediate for the preparation of Isothiazoloquinolones, which exhibit enhanced antistaphylococcal activities against multidrug-resistant strains of Staphylococcus aureus. These Isothiazoloquinolones have the potential to combat antibiotic-resistant bacterial infections, addressing a significant global health concern.
Additionally, tert-Butyl 5-bromoisoindoline-2-carboxylate is used as a precursor in the synthesis of substituted isoindolines, which act as inhibitors of dipeptidyl peptidase 8/9 (DPP8/9). DPP8/9 inhibitors are of interest in the development of treatments for various diseases, including type 2 diabetes and neurodegenerative disorders, due to their role in regulating peptide processing and inflammation.
Check Digit Verification of cas no
The CAS Registry Mumber 201940-08-1 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,0,1,9,4 and 0 respectively; the second part has 2 digits, 0 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 201940-08:
(8*2)+(7*0)+(6*1)+(5*9)+(4*4)+(3*0)+(2*0)+(1*8)=91
91 % 10 = 1
So 201940-08-1 is a valid CAS Registry Number.
InChI:InChI=1/C13H16BrNO2/c1-13(2,3)17-12(16)15-7-9-4-5-11(14)6-10(9)8-15/h4-6H,7-8H2,1-3H3
201940-08-1Relevant articles and documents
APPLICATION OF MONOCYCLIC BETA-LACTAM COMPOUND IN PHARMACY
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, (2021/11/04)
An application of a compound represented by formula (I) and pharmaceutically acceptable salts thereof in preparation of a drug for treating pneumonia.
CRYSTAL OF DPP-IV LONG-ACTING INHIBITOR AND SALT
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, (2019/09/30)
The present application relates a crystal of a compound represented by Formula (I), a salt thereof, and a crystal of the salt thereof, a method for preparing the crystal of the compound represented by Formula (I), the salt thereof, and the crystal of the
2-Amino-2,3-dihydro-1 H-indene-5-carboxamide-Based Discoidin Domain Receptor 1 (DDR1) Inhibitors: Design, Synthesis, and in Vivo Antipancreatic Cancer Efficacy
Zhu, Dongsheng,Huang, Huocong,Pinkas, Daniel M.,Luo, Jinfeng,Ganguly, Debolina,Fox, Alice E.,Arner, Emily,Xiang, Qiuping,Tu, Zheng-Chao,Bullock, Alex N.,Brekken, Rolf A.,Ding, Ke,Lu, Xiaoyun
, p. 7431 - 7444 (2019/08/20)
A series of 2-amino-2,3-dihydro-1H-indene-5-carboxamides were designed and synthesized as new selective discoidin domain receptor 1 (DDR1) inhibitors. One of the representative compounds, 7f, bound with DDR1 with a Kd value of 5.9 nM and suppre
