201991-24-4

Basic information

• Product Name: 2-Acetyl-1-piperidinecarboxylic acid tert-butyl ester
• Synonyms: 2-Acetyl-1-piperidinecarboxylic acid tert-butyl ester;2-Acetyl-piperidine-1-carboxylic acid tert-butyl ester;1-Piperidinecarboxylic acid, 2-acetyl-, 1,1-dimethylethyl ester;1-Boc-2-acetylpiperidine;tert-butyl 2-acetylpiperidine-1-carboxylate;2-Acetyl-N-Boc-piperidine
• CAS NO: 201991-24-4
• Molecular Formula: C12H21NO3
• Molecular Weight: 227.302
• Mol File: 201991-24-4.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 312.365 °C at 760 mmHg
• Flash Point: 142.714 °C
• Appearance: /
• Density: 1.052
• PKA: -3.16±0.40(Predicted)
• CAS DataBase Reference: 2-Acetyl-1-piperidinecarboxylic acid tert-butyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Acetyl-1-piperidinecarboxylic acid tert-butyl ester(201991-24-4)
• EPA Substance Registry System: 2-Acetyl-1-piperidinecarboxylic acid tert-butyl ester(201991-24-4)

Safety Data

• Hazardous Substances Data: 201991-24-4(Hazardous Substances Data)

Usage

General Description

2-Acetyl-1-piperidinecarboxylic acid tert-butyl ester, also known as acetyl piperidine, is a chemical compound commonly used in the production of pharmaceuticals. It is an acetyl derivative of piperidine, a six-membered heterocyclic ring consisting of five carbon atoms and one nitrogen atom. The tert-butyl ester group in the compound provides stability and protection to the molecule. Acetyl piperidine is often utilized as a building block in the synthesis of various pharmaceuticals and has potential applications in medicinal chemistry. Its unique structure and functional groups make it a valuable intermediate for the creation of bioactive compounds, making it an important and versatile chemical in the pharmaceutical industry.

InChI:InChI=1S/C12H21NO3/c1-9(14)10-7-5-6-8-13(10)11(15)16-12(2,3)4/h10H,5-8H2,1-4H3

Upstream product

• 24424-99-5 di-tert-butyl dicarbonate 
• 75-16-1 methylmagnesium bromide 
• 211310-10-0 2-(methoxy-N-methylcarbamoyl)piperidine-1-carboxylic acid tert-butyl ester 
• 4043-87-2 pipecolic Acid 
• 98303-20-9 1-(tert-butoxycarbonyl)piperidine-2-carboxylic acid 
• 74651-77-7 2-(tert-butoxycarbonyloxyimino)-2-phenylacetonitrile 
• 201991-23-3 2-(Pyridin-2-ylsulfanylcarbonyl)-piperidine-1-carboxylic acid tert-butyl ester 

Downstream Products

• 1422193-31-4 2-[2-(2-aminophenyl)-1-methylvinyl]piperidine-1-carboxylic acid tert-butyl ester 
• 1422193-39-2 (Z)-1-Boc-2-(1-(2-azidophenyl)prop-1-en-2-yl)piperidine 
• 1422192-38-8 (Z)-2-(1-(2-azidophenyl)prop-1-en-2-yl)-1-(phenylsulfonyl)piperidine 
• 128372-98-5 tert-butyl (6-oxoheptyl)carbamate 

Relevant articles and documents

MODIFIED PROTEINS AND PROTEIN DEGRADERS

Provided herein are compounds, pharmaceutical compositions, and methods for binding or degrading target proteins. Further provided herein are compounds having a DNA damage-binding protein 1 (DDB1) binding moiety. Some such embodiments include a linker. Some such embodiments include a target protein binding moiety. Further provided herein are ligand-DDB1 complexes. Further provided herein are in vivo modified DDB1 proteins.

Microwave-assisted synthesis of novel (5-nitropyridin-2-yl)alkyl and (5-nitropyridin-3-yl)alkyl carbamates

A straightforward approach to novel (5-nitropyridin-2-yl)alkyl and (5-nitropyridin-3-yl)alkyl carbamate building blocks is presented in this study. Their construction is achieved by condensation of N-carbamate a- and β-amino carbonyl derivatives with l-methyl-3,5-dinitro-2-pyridone 1 under microwave irradiation. Judiciously chosen modifications in the nature of the parent carbonyl starting material has influenced the regiochemical outcome of the reaction and allowed an efficient access to novel nitrogen-containing scaffolds. Compounds sharing morphological similarities have been gathered in three libraries differing from each other in a single structural parameter.