20218-55-7

Basic information

• Product Name: (S)-(-)-N-METHYL-1-(1-NAPHTHYL)ETHYLAMINE
• Synonyms: (S)-(-)-N-METHYL-1-(1-NAPHTHYL)ETHYLAMINE;(S)-N-METHYL-1-(NAPHTHALEN-1-YL)ETHANAMINE;S(-)-N-METHYL-ALPHA-(1-NAPHTHYL)ETHYLAMINE;(1S)-N-methyl-1-naphthalen-1-ylethanamine
• CAS NO: 20218-55-7
• Molecular Formula: C₁₃H₁₅N
• Molecular Weight: 185.26
• Product Categories: Amines;Chiral Building Blocks;Organic Building Blocks
• Mol File: 20218-55-7.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 203 °C(lit.)
• Flash Point: 113 °C
• Appearance: colorless liquid
• Density: 1.04 g/mL at 25 °C(lit.)
• Vapor Pressure: 0.00197mmHg at 25°C
• Refractive Index: n20/D 1.605(lit.)
• CAS DataBase Reference: (S)-(-)-N-METHYL-1-(1-NAPHTHYL)ETHYLAMINE(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-(-)-N-METHYL-1-(1-NAPHTHYL)ETHYLAMINE(20218-55-7)
• EPA Substance Registry System: (S)-(-)-N-METHYL-1-(1-NAPHTHYL)ETHYLAMINE(20218-55-7)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• Hazardous Substances Data: 20218-55-7(Hazardous Substances Data)

Usage

General Description

(S)-(-)-N-METHYL-1-(1-NAPHTHYL)ETHYLAMINE, also known as pure L-amphetamine, is a chemical compound with the molecular formula C13H15N. It is a chiral amphetamine derivative that is commonly used in the synthesis of pharmaceutical drugs and research chemicals. (S)-(-)-N-METHYL-1-(1-NAPHTHYL)ETHYLAMINE is a powerful central nervous system stimulant that affects the release and reuptake of various neurotransmitters, such as dopamine, norepinephrine, and serotonin. It is also used in the production of psychoactive substances and as a precursor in the synthesis of other amphetamine derivatives. (S)-(-)-N-METHYL-1-(1-NAPHTHYL)ETHYLAMINE has potential applications in the field of medicine, neuroscience, and pharmacology due to its psychoactive and stimulant properties.

InChI:InChI=1/C13H15N/c1-10(14-2)12-9-5-7-11-6-3-4-8-13(11)12/h3-10,14H,1-2H3/t10-/m0/s1

Upstream product

• 941-98-0 1'-naphthacetophenone 
• 73765-07-8 rac-1-(1-bromoethyl)naphthalene 
• 74-89-5 methylamine 
• 50-00-0 formaldehyd 
• 10420-89-0 (S)-1-(1-Naphthyl)ethylamine 
• 109-94-4 formic acid ethyl ester 
• 87782-91-0 ((S)-1-Naphthalen-1-yl-ethyl)-carbamic acid ethyl ester 

Downstream Products

• 1200401-06-4 (S)-N-(4-tert-butylbenzyl)-N-methyl-1-(naphthalen-1-yl)ethanamine 
• 1217809-88-5 N-(1-(naphthalen-1-yl)ethyl)-3-(3-(trifluoromethyl)phenyl)propan-1-amine hydrochloride 
• 65503-07-3 (E)-N-methyl-N-(3-phenyl-2-propenyl)-1-naphthalene-1-ethanamine 
• 98978-37-1 3--1-phenyl-1-propanol 
• 98978-30-4 3--1-phenyl-1-propanone 

Relevant articles and documents

1-(1-Naphthyl)ethylamine and Derivatives thereof as Chiral Modifiers in the Enantioselective Hydrogenation of Ethyl Pyruvate over Pt-Alumina

Catalytic quantities of (R)- or (S)-1-(1-naphthyl)ethylamine induce up to 82percent e.e. in the hydrogenation of ethyl pyruvate over Pt-alumina, the actual modifier responsible for enantioselection being the secondary amine resulting from imine formation

Stereogenic Lock in 1-Naphthylethanamine Complexes for Catalyst and Auxiliary Design: Structural and Reactivity Analysis for Cycloiridated Pseudotetrahedral Complexes

A series of optically active pseudo-tetrahedral five-membered cyclometalated 1-naphthylethanamine iridium(III) complexes were prepared and characterized to analyze the efficacy of the stereogenic conformational lock in both solid and solution phases. The synthesis of the iridacycles was diastereoselective, and the compounds were found to be conformationally rigid. In comparison to its phenyl derivative, the structural lock prevented oxidation of the amine moiety within the five-membered organometallic ring during its synthesis. With up to three stereogenic centers in one of the naphthalene complexes, the stereochemistry of the metallacycle remained stable to both thermal and chemical changes. In terms of catalytic performance, the complexes displayed excellent activity for the asymmetric hydrogen transfer reaction, albeit with modest enantioselectivities.

Diastereoselective carbozincation of propargylic amines

The carbometalation of propargylic amines derived from methylbenzylamine takes place with good 1,3-diastereoselection in the presence of Lewis acids.