202211-97-0

Basic information

• Product Name: 1-Benzyloxy-2-(tert-butyl-dimethyl-silanyl)-1H-imidazole
• CAS NO: 202211-97-0
• Molecular Weight: 288.465
• Mol File: 202211-97-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 1-Benzyloxy-2-(tert-butyl-dimethyl-silanyl)-1H-imidazole(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Benzyloxy-2-(tert-butyl-dimethyl-silanyl)-1H-imidazole(202211-97-0)
• EPA Substance Registry System: 1-Benzyloxy-2-(tert-butyl-dimethyl-silanyl)-1H-imidazole(202211-97-0)

Safety Data

• Hazardous Substances Data: 202211-97-0(Hazardous Substances Data)

Upstream product

• 121779-19-9 1-(benzyloxy)imidazole 
• 18162-48-6 tert-butyldimethylsilyl chloride 

Downstream Products

• 202211-96-9 1-Benzyloxy-1H-imidazole-2-carbaldehyde 
• 202211-98-1 1-(benzyloxy)-2-chloroimidazole 
• 121779-19-9 1-(benzyloxy)imidazole 

Relevant articles and documents

Synthesis of 2-Substituted 1-Hydroxyhnidazoles through Directed Lithiation

Benzylation of 3-hydroxyimidazole 1-oxide gave 3-(benzyloxy)imidazole 1-oxide, which was deoxygenated with phosphorous trichloride to produce 1-(benzyloxy)imidazole. 1-(Benzyloxy)imidazole was deprotonated selectively at C-2 by n-butyllithium. The anion formed was reacted with electrophiles to give 1-(benzyloxy)imidazoles with carbon, halogen, silicon, or sulfur substituents at the 2-position. Subsequent debenzylation afforded 2-substituted 1-hydroxyimidazoles which in turn could be deoxygenated to give 2-substituted imidazoles.