202341-40-0

Basic information

• Product Name: 4-nitro-N-(p-carboxyphenyl)-1,8-naphthalimide
• CAS NO: 202341-40-0
• Molecular Weight: 362.298
• Mol File: 202341-40-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 4-nitro-N-(p-carboxyphenyl)-1,8-naphthalimide(CAS DataBase Reference)
• NIST Chemistry Reference: 4-nitro-N-(p-carboxyphenyl)-1,8-naphthalimide(202341-40-0)
• EPA Substance Registry System: 4-nitro-N-(p-carboxyphenyl)-1,8-naphthalimide(202341-40-0)

Safety Data

• Hazardous Substances Data: 202341-40-0(Hazardous Substances Data)

Upstream product

• 150-13-0 4-amino-benzoic acid 
• 34087-02-0 2-nitro-1,8-naphthalic anhydride 

Relevant articles and documents

Method of inhibiting binding of nerve growth factor to p75 NTR receptor

The present invention relates to compositions which inhibit the binding of nerve growth factor to the p75NTRcommon neurotrophin receptor and methods of use thereof. In one embodiment, the compound which inhibits binding of nerve growth factor to p75NTRcomprises, particularly when bound to nerve growth factor, at least two of the following: (1) a first electronegative atom or functional group positioned to interact with Lys34of nerve growth factor; (2) a second electronegative atom or functional group positioned to interact with Lys95of nerve growth factor; (3) a third electronegative atom or functional group positioned to interact with Lys88of nerve growth factor; (4) a fourth electronegative atom or functional group positioned to interact with Lys32of nerve growth factor; and (5) a hydrophobic moiety which interacts with the hydrophobic region formed by Ile31, Phe101and Phe86of nerve growth factor.