202343-12-2 Usage
Description
(2R,4S,5R,6R)-5-Acetylamino-2-azido-4-hydroxy-6-((1R,2R)-1,2,3-trihydroxy-propyl)-tetrahydro-pyran-2-carboxylic acid is a complex organic molecule characterized by a tetrahydropyran ring and various functional groups, including acetylamino, azido, hydroxy, and carboxylic acid. It possesses a specific configuration of chiral centers, indicated by the R and S designations, and features an acetylamino substituent at the 5-position and an azido group at the 2-position. (2R,4S,5R,6R)-5-Acetylamino-2-azido-4-hydroxy-6-((1R,2R)-1,2,3-trihydroxy-propyl)-tetrahydro-pyran-2-carboxylic acid also includes a tetrahydropyran-2-carboxylic acid moiety, which contributes to its overall structure and properties. It may have potential applications in medicinal chemistry, biochemistry, or organic synthesis, depending on its specific properties and reactivity.
Uses
Used in Medicinal Chemistry:
(2R,4S,5R,6R)-5-Acetylamino-2-azido-4-hydroxy-6-((1R,2R)-1,2,3-trihydroxy-propyl)-tetrahydro-pyran-2-carboxylic acid is used as a pharmaceutical candidate for the development of new drugs due to its unique structure and functional groups, which may exhibit specific biological activities and interactions with biological targets.
Used in Biochemistry:
In biochemistry, (2R,4S,5R,6R)-5-Acetylamino-2-azido-4-hydroxy-6-((1R,2R)-1,2,3-trihydroxy-propyl)-tetrahydro-pyran-2-carboxylic acid may be utilized as a research tool to study enzyme mechanisms, protein interactions, or other biochemical processes, given its complex structure and functional groups.
Used in Organic Synthesis:
(2R,4S,5R,6R)-5-Acetylamino-2-azido-4-hydroxy-6-((1R,2R)-1,2,3-trihydroxy-propyl)-tetrahydro-pyran-2-carboxylic acid is used as a synthetic intermediate or building block in the synthesis of more complex organic compounds, taking advantage of its reactivity and structural features to create novel molecules with potential applications in various fields.
Check Digit Verification of cas no
The CAS Registry Mumber 202343-12-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,0,2,3,4 and 3 respectively; the second part has 2 digits, 1 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 202343-12:
(8*2)+(7*0)+(6*2)+(5*3)+(4*4)+(3*3)+(2*1)+(1*2)=72
72 % 10 = 2
So 202343-12-2 is a valid CAS Registry Number.
202343-12-2Relevant articles and documents
Synthesis and biological evaluation of non-hydrolyzable 1,2,3-triazole-linked sialic acid derivatives as neuraminidase inhibitors
Weiwer, Michel,Chen, Chi-Chang,Kemp, Melissa M.,Linhardt, Robert J.
body text, p. 2611 - 2620 (2009/09/29)
αa-Sialic acid, azide 1 has been used as a substrate for the efficient preparation of 1,2,3-triazole derivatives of sialic acid using the copper-catalyzed azide-alkyne Huisgen cycloaddition ("click chemistry"). Our approach is to generate nonnatural N-glycosides of sialic acid, that are resistant to neuraminidase-catalyzed hydrolysis as opposed, to the natural Oglycosides. These N-glycosides would act as neuraminidase inhibitors to prevent the release of new virions. As a preliminary study, a small library of 1,2,3-triazole-linked sialic acid, derivatives has been synthesized in 71-89% yield. A. disaccharide mimic of sialic acid, has also been prepared using the α-sialic acid azide 1 and a C-8 propargyl sialic acid acceptor in 68 % yield. A model sialic acid coated dendrimer was also synthesized from a perpropargylated pentaerythritol acceptor. These novel sialic acid derivatives were then evaluated, as potential neuraminidase inhibitors using a 96-well plate fluorescence assay; micromolar IC50 values were observed, comparable to the known sialidase inhibitor Neu5Ac2en.
