202396-52-9

Basic information

• Product Name: 6-chloro-2-(chloromethyl)-1,3-benzoxazole
• Synonyms: 6-chloro-2-(chloromethyl)-1,3-benzoxazole
• CAS NO: 202396-52-9
• Molecular Formula: C8H5Cl2NO
• Molecular Weight: 202.0374
• Mol File: 202396-52-9.mol
• Article Data: 2

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 6-chloro-2-(chloromethyl)-1,3-benzoxazole(CAS DataBase Reference)
• NIST Chemistry Reference: 6-chloro-2-(chloromethyl)-1,3-benzoxazole(202396-52-9)
• EPA Substance Registry System: 6-chloro-2-(chloromethyl)-1,3-benzoxazole(202396-52-9)

Safety Data

• Hazardous Substances Data: 202396-52-9(Hazardous Substances Data)

Upstream product

• 28443-50-7 2-amino-5-chlorophenol 
• 36743-66-5 ethyl chloroacetimidate hydrochloride 
• 74974-54-2 2-chloro-1,1,1-trimethoxyethane 

Relevant articles and documents

Anti-oligomerization sheet molecules: Design, synthesis and evaluation of inhibitory activities against α-synuclein aggregation

Aggregation of α-synuclein (α-Syn) play a key role in the development of Parkinson Disease (PD). One of the effective approaches is to stabilize the native, monomeric protein with suitable molecule ligands. We have designed and synthesized a series of sheet-like conjugated compounds which possess different skeletons and various heteroatoms in the two blocks located at both ends of linker, which have good π-electron delocalization and high ability of hydrogen-bond formation. They have shown anti-aggregation activities in vitro towards α-Syn with IC50 down to 1.09 μM. The molecule is found binding in parallel to the NACore within NAC domain of α-Syn, interfering aggregation of NAC region within different α-Syn monomer, and further inhibiting or slowing down the formation of α-Syn oligomer nuclei at lag phase. The potential inhibitor obtained by our strategy is considered to be highly efficient to inhibit α-Syn aggregation.