202409-80-1

Basic information

• Product Name: 5-chloro-3-(4-methylsulfonylphenyl)-2-pyridinamine
• Synonyms: 5-chloro-3-(4-methylsulfonylphenyl)-2-pyridinamine
• CAS NO: 202409-80-1
• Molecular Weight: 282.751
• Mol File: 202409-80-1.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: 5-chloro-3-(4-methylsulfonylphenyl)-2-pyridinamine(CAS DataBase Reference)
• NIST Chemistry Reference: 5-chloro-3-(4-methylsulfonylphenyl)-2-pyridinamine(202409-80-1)
• EPA Substance Registry System: 5-chloro-3-(4-methylsulfonylphenyl)-2-pyridinamine(202409-80-1)

Safety Data

• Hazardous Substances Data: 202409-80-1(Hazardous Substances Data)

Upstream product

• 1443542-63-9 N-[5-chloro-3-(4-methylsulfonylphenyl)pyridin-2-yl]pyridin-1-ium-1-aminide 
• 171774-38-2 N-(3-bromo-5-chloropyridin-2-yl)pyridin-1-ium-1-aminide 
• 149104-88-1 4-methanesulphonylphenylboronic acid 
• 26163-03-1 2-amino-3-bromo-5-chloropyridine 
• 1072-98-6 5-chloro-2-pyridylamine 
• 217090-19-2 5-chloro-3-(4-methylthiophenyl)-2-pyridinamine 

Downstream Products

• 202409-85-6 5-chloro-3-[4-(methylsulfonyl)phenyl]pyridin-2(1H)-one 
• 202409-81-2 2-bromo-5-chloro-3-(4-(methylsulfonyl)phenyl)pyridine 
• 202409-33-4 etoricoxib 
• 202409-31-2 5-Chloro-3-(4-(methylsulfonyl)phenyl)-2-(3-pyridinyl)pyridine 
• 202409-86-7 2,5-dichloro-3-[4-(methylsulfonyl)phenyl]pyridine 

Relevant articles and documents

A facile synthesis of 3,5-halo and aryl 1H-pyridin-2-ones from pyridinium N-(pyridin-2-yl)aminide

The synthesis of halogenated and arylated 1H-pyridin-2-ones starting from pyridinium N-(pyridin-2-yl)aminides is described. The synthetic pathway involves the reaction of pyridinium N-(5-bromopyridin-2-yl)aminide, N-(3-bromo-5- chloropyridin-2-yl)aminide or N-(3,5-dibromopyridin-2-yl)aminide with different boronic acids to afford monosubstituted and disubstituted aminides in good yields. An additional bromination in the 3-position of N-(5-arylpyridin-2-yl) aminides was performed. Finally, reduction of the N-N bond followed by the reaction of the corresponding 2-aminopyridines with sodium nitrite/sulfuric acid in water yields 3,5-disubstituted 1H-pyridin-2-ones in good yields.

Substituted pyridines as selective cyclooxygenase-2 inhibitors

The invention encompasses the novel compound of Formula I as well as a method of treating COX-2 mediated diseases comprising administration to a patient in need of such treatment of a non-toxic therapeutically effective amount of a compound of Formula I. STR1 The invention also encompasses certain pharmaceutical compositions for treatment of COX-2 mediated diseases comprising compounds of Formula I.

2-pyridinyl-3(4-methylsulfonyl)phenylpyridines: Selective and orally active cyclooxygenase-2 inhibitors

A series of novel 2-pyridinyl-3-(4-methylsulfonyl)phenylpyridines has been synthesized and evaluated with respect to their ability to inhibit the isozymes of cyclooxygenase, COX-1, and COX-2. Optimum COX-2 activity is observed by introduction of a substituent at C5 of the central pyridine. 5- Chloro-3-(4-methylsulfonyl)phenyl-2(2-methyl-5-pyridinyl)pyridine 33 was identified as the optimum compound in this series.