202666-31-7Relevant articles and documents
Preparation of arylmercapturic acids by S-arylation of N,N′- diacetylcystine
Krouzelka, Jan,Linhart, Igor
, p. 6336 - 6340 (2009)
A simple convenient method has been developed for the preparation of N-acetyl-S-arylcysteines based on the Chan-Lam-Evans arylation of N,N′-diacetylcystine dimethyl ester with arylboronic acids and used to synthesize a series of arylmercapturic acids. Unlike copper-mediated N-arylation, the S-arylation of neither cysteine nor cystine derivatives proceeded satisfactorily in the presence of air. Wiley-VCH Verlag GmbH & Co. KGaA.
α-Amino-β-sulphone hydroxamates as potent MMP-13 inhibitors that spare MMP-1
Becker, Daniel P,Barta, Thomas E,Bedell, Louis,DeCrescenzo, Gary,Freskos, John,Getman, Daniel P,Hockerman, Susan L,Li, Madeleine,Mehta, Pramod,Mischke, Brent,Munie, Grace E,Swearingen, Craig,Villamil, Clara I
, p. 2719 - 2722 (2007/10/03)
A series of α-amino-β-sulphone hydroxamates was prepared and evaluated for potency versus MMP-13 and selectivity versus MMP-1. Various substituents were employed on the α-amino group (P1 position), as well as different groups attached to the su
