202743-06-4Relevant articles and documents
A facile approach to trans-4,5-pyrrolidine lactam and application in the synthesis of nemonapride and streptopyrrolidine
Huang, Wei,Ma, Jing-Yi,Yuan, Mu,Xu, Long-Fei,Wei, Bang-Guo
, p. 7829 - 7837 (2011/10/12)
An efficient approach to trans-4-hydroxylpyrrolidine lactams 1 starting from amino acid is described. The utility of this method has been demonstrated in the synthesis of antipsychotic nemonapride 3 and antiangiogenic streptopyrrolidine 4. Compared four s