202865-64-3

Basic information

• Product Name: 4-BROMO-2-FLUOROBENZALDOXIME
• Synonyms: 4-BROMO-2-FLUOROBENZALDOXIME;4-BROMO-2-FLUOROBENZALDOXINE;4-BroMo-2-fluorobenzaldehyde oxiMe
• CAS NO: 202865-64-3
• Molecular Formula: C₇H₅BrFNO
• Molecular Weight: 218.02
• Product Categories: Aromatic Hydrazides, Hydrazines, Hydrazones and Oximes
• Mol File: 202865-64-3.mol
• Article Data: 9

Chemical Properties

• Boiling Point: 250.367 °C at 760 mmHg
• Flash Point: 105.218 °C
• Appearance: /
• Density: 1.626 g/cm³
• Vapor Pressure: 0.011mmHg at 25°C
• Refractive Index: 1.564
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 4-BROMO-2-FLUOROBENZALDOXIME(CAS DataBase Reference)
• NIST Chemistry Reference: 4-BROMO-2-FLUOROBENZALDOXIME(202865-64-3)
• EPA Substance Registry System: 4-BROMO-2-FLUOROBENZALDOXIME(202865-64-3)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36/37/39
• Hazardous Substances Data: 202865-64-3(Hazardous Substances Data)

Usage

General Description

4-Bromo-2-fluorobenzaldoxime is a chemical compound with the molecular formula C7H5BrFNO. It is an aldoxime derivative, which is a type of organic compound that contains a functional group with the structure R1R2C=NOH. This specific compound is used in various chemical reactions and processes, particularly in the synthesis of pharmaceuticals and agrochemicals. It is also utilized in the research and development of new compounds for medicinal and agricultural purposes. Due to its specific structure and properties, 4-bromo-2-fluorobenzaldoxime has potential applications in the production of various important chemicals and is the subject of ongoing scientific investigation and study.

InChI:InChI=1/C7H5BrFNO/c8-6-2-1-5(4-10-11)7(9)3-6/h1-4,11H/b10-4+

Upstream product

• 57848-46-1 4-bromo-2-fluorobenzaldehyde 

Downstream Products

• 698982-64-8 [3-(4-bromo-2-fluorophenyl)-4,5-dihydroisoxazol-5-yl]methanol 
• 57848-46-1 4-bromo-2-fluorobenzaldehyde 
• 1060802-88-1 6-bromo-benzo[d]isoxazole 
• 883231-04-7 3-fluoro-4-(hydroxyimino-methyl)phenylboronic acid 
• 105942-08-3 4-bromo-6-fluorobenzonitrile 
• 883230-73-7 [3-(4-bromo-2-fluorophenyl)isoxazol-5-yl]methanol 
• 334971-44-7 4-bromo-2-fluoro-N-hydroxybenzenecarboximidoyl chloride 

Relevant articles and documents

Discovery of Natural Product-Based Fungicides (II): Semisynthesis and Biological Activity of Sarisan Attached 3-Phenylisoxazolines as Antifungal Agents

Many phytopathogenic fungi cause severe damage to crop yields. In continuation of our research aimed at the discovery and development of natural products-based fungicides, a series of thirty-one sarisan attached 3-phenylisoxazolines were synthesized and evaluated for their antifungal activities against five phytopathogenic fungi (B. cinerea, C. lagenarium, A. solani, F. solani, and F. graminearum). Among all title sarisan derivatives, compounds IV2, IV14 and IV23 showed potent antifungal activity against some phytopathogenic fungi. In particular, compound IV2 exhibited a broad-spectrum and more potent antifungal activity against A. solani, F. solani, and F. graminearum than the commercial fungicide Hymexazol. In addition, compounds IV2, IV14 and IV23 also displayed relative low toxicity on normal NRK-52E cells. This work will give some insights into the development of sarisan derivatives as new fungicide candidates in plant protection.

GLUCOSYLCERAMIDE SYNTHASE INHIBITORS FOR THE TREATMENT OF DISEASES

Described herein are compounds of Formula I, methods of making such compounds, pharmaceutical compositions and medicaments containing such compounds, and methods of using such compounds to treat or prevent diseases or conditions associated with the enzyme glucosylceramide synthase (GCS).

Fragment-based discovery of JAK-2 inhibitors

Fragment-based hit identification coupled with crystallographically enabled structure-based drug design was used to design potent inhibitors of JAK-2. After two iterations from fragment 1, we were able to increase potency by greater than 500-fold to provide sulfonamide 13, a 78-nM JAK-2 inhibitor.