20299-15-4 Usage
Description
2-thio-5-<(methylcarboxy)methyl>uridine, also known as 5-(methoxycarbonylmethyl)-2-thiouridine, is a trace nucleoside that has been isolated from yeast transfer RNA. It is a modified ribonucleotide found in the anticodon at the wobble position of some Saccharomyces cerevisiae bacteria. 2-thio-5-<(methylcarboxy)methyl>uridine plays a significant role in the study of RNA modifications and the epitranscriptome of human neural stem cells.
Uses
Used in Biological Studies:
2-thio-5-<(methylcarboxy)methyl>uridine is used as an analyte in biological studies for attomole quantification and global profiling of RNA modifications. This application is crucial for understanding the epitranscriptome of human neural stem cells, which can provide valuable insights into cellular processes and gene regulation.
Used in Computational Studies:
In biological computational studies, 2-thio-5-<(methylcarboxy)methyl>uridine is employed to provide insights into the effects of modified ribonucleotides and Mg2+ on the structures and stabilities of transfer RNAs (tRNAs). This information is essential for understanding the role of these modifications in protein synthesis and other cellular functions.
Used in Pharmaceutical Research:
As a modified ribonucleotide, 2-thio-5-<(methylcarboxy)methyl>uridine may have potential applications in the development of new drugs and therapies targeting RNA-related diseases. Its unique properties and interactions with other biomolecules make it a promising candidate for further research and development in the pharmaceutical industry.
Used in Diagnostics:
The ability to quantify 2-thio-5-<(methylcarboxy)methyl>uridine at the attomole level could potentially be applied in the development of highly sensitive diagnostic tools for detecting and monitoring various diseases and conditions related to RNA modifications and cellular processes.
Check Digit Verification of cas no
The CAS Registry Mumber 20299-15-4 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,0,2,9 and 9 respectively; the second part has 2 digits, 1 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 20299-15:
(7*2)+(6*0)+(5*2)+(4*9)+(3*9)+(2*1)+(1*5)=94
94 % 10 = 4
So 20299-15-4 is a valid CAS Registry Number.
20299-15-4Relevant articles and documents
Synthesis of 2-thio-5-carboxymethyluridine methyl ester: a component of transfer RNA.
Baczynskyj,Biemann,Fleysher,Hall
, p. 1202 - 1203 (1969)
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ALTERNATIVE NUCLEIC ACID MOLECULES AND USES THEREOF
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, (2016/06/28)
The present disclosure provides alternative nucleosides, nucleotides, and nucleic acids, and methods of using them.
MODIFIED NUCLEIC ACID MOLECULES AND USES THEREOF
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Page/Page column 299, (2014/07/07)
The present disclosure provides modified nucleosides, nucleotides, and nucleic acids, and methods of using them.
