203056-18-2Relevant articles and documents
Concise and facile synthesis of (R,R)-dexmethylphenidate hydrochloride and its three stereoisomers
Li, Chunzheng,Ji, Yuanbo,Cao, Qing,Li, Jianqi,Li, Bonan
supporting information, p. 1301 - 1306 (2017/07/12)
A new and concise route is reported for the first time for the preparation of four stereoisomers of dexmethylphenidate hydrochloride starting from a single reactant, 2-benzyolpyridine, through an eight-step reaction process, which includes hydrogenation,
A concise stereoselective total synthesis of (2R,2′R)-threo-(+)- methyl-phenidate via a ring-closing metathesis protocol
Krishna, Palakodety Radha,Lopinti, Krishnarao
, p. 1742 - 1744 (2007/12/31)
In the synthesis of (2R,2′R)-threo-(+)-methylphenidate, a ring-closing metathesis approach was adopted to construct the piperidine ring, while Sharpless asymmetric epoxidation was used for the efficient generation of two contiguous stereocenters. Georg Th
Asymmetric synthesis and pharmacology of methylphenidate and its para- substituted derivatives
Thai, Dung L.,Sapko, Michael T.,Reiter, Clara T.,Bierer, Donald E.,Perel, James M.
, p. 591 - 601 (2007/10/03)
We report the first asymmetric synthesis of the individual enantiomers of methylphenidate (1). From d-pipecolic acid, the (2R,2'R) and (2S,2'R) enantiomers of 1 were obtained in >99% optical purity while the (2S,2'S) and (2R,2'S) enantiomers of 1 were der
