203180-30-7

Basic information

• Product Name: (R)-1-{(S)-1-[4-(Benzo[1,3]dioxole-5-sulfonyl)-phenyl]-ethyl}-2-methyl-4-piperidin-4-yl-piperazine
• CAS NO: 203180-30-7
• Molecular Weight: 471.621
• Mol File: 203180-30-7.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: (R)-1-{(S)-1-[4-(Benzo[1,3]dioxole-5-sulfonyl)-phenyl]-ethyl}-2-methyl-4-piperidin-4-yl-piperazine(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-1-{(S)-1-[4-(Benzo[1,3]dioxole-5-sulfonyl)-phenyl]-ethyl}-2-methyl-4-piperidin-4-yl-piperazine(203180-30-7)
• EPA Substance Registry System: (R)-1-{(S)-1-[4-(Benzo[1,3]dioxole-5-sulfonyl)-phenyl]-ethyl}-2-methyl-4-piperidin-4-yl-piperazine(203180-30-7)

Safety Data

• Hazardous Substances Data: 203180-30-7(Hazardous Substances Data)

Upstream product

• 203186-29-2 1-tert-butoxycarbonyl-4-{4-[1(S)-(4-bromophenyl)-ethyl]-3(R)-methylpiperazin-1-yl}-piperidine 
• 441772-07-2 (R)-1-[(S)-1-(4-Bromo-phenyl)-ethyl]-6-methyl-piperazine-2,5-dione 
• 441772-08-3 (R)-1-[(S)-1-(4-Bromo-phenyl)-ethyl]-2-methyl-piperazine 
• 182141-70-4 N-[(1S)-1-(4-bromophenyl)ethyl]-2,2,2-trifluoroacetamide 
• 27298-97-1 (S)-1-(4-bromophenyl)ethylamine 
• 2354-91-8 (S)-2,2,2-trifluoro-(α-methylbenzyl)acetamide 
• 442868-88-4 (R)-4-{(S)-1-[4-(Benzo[1,3]dioxole-5-sulfonyl)-phenyl]-ethyl}-3-methyl-piperazine-1-carboxylic acid tert-butyl ester 
• 203180-27-2 (R)-1-{(S)-1-[4-(Benzo[1,3]dioxole-5-sulfonyl)-phenyl]-ethyl}-2-methyl-piperazine 
• 203180-24-9 Methanesulfonic acid (R)-1-[4-(benzo[1,3]dioxole-5-sulfonyl)-phenyl]-ethyl ester 
• 442868-87-3 1-[4-(benzo[1,3]dioxole-5-sulfonyl)-phenyl]-ethanone 
• 203180-21-6 1-[4-(benzo[1,3]dioxol-5-ylsulfanyl)-phenyl]-ethanone 
• 163765-44-4 (R)-tert-butyl 3-methylpiperazine-1-carboxylate 
• 5876-51-7 5-iodo-1,3-benzodioxole 
• 403-42-9 1-(4-fluorophenyl)ethanone 

Relevant articles and documents

Synthesis and structure-Activity relationships of M2-Selective muscarinic receptor ligands in the 1-[4-(4-Arylsulfonyl)-phenylmethyl]-4-(4-piperidinyl)-piperazine family

The synthesis and muscarinic binding properties of compounds based on the 1-[4-(4-arylsulfonyl)phenylmethyl]-4-(1-aroyl-4-piperidinyl)-piperazine skeleton are described. For compounds, substituted with appropriately configured methyl groups at the benzylic center and at the piperazine 2-position, high levels of selective, M2 subtype affinity could be obtained, particularly when the terminal N-aroyl residue was ortho-substituted.