203186-02-1

Basic information

• Product Name: 4-[2-(4-bromophenyl)-1,3-dioxolan-2-yl]-piperidine
• Synonyms: 4-[2-(4-bromophenyl)-1,3-dioxolan-2-yl]-piperidine
• CAS NO: 203186-02-1
• Molecular Weight: 312.206
• Mol File: 203186-02-1.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 4-[2-(4-bromophenyl)-1,3-dioxolan-2-yl]-piperidine(CAS DataBase Reference)
• NIST Chemistry Reference: 4-[2-(4-bromophenyl)-1,3-dioxolan-2-yl]-piperidine(203186-02-1)
• EPA Substance Registry System: 4-[2-(4-bromophenyl)-1,3-dioxolan-2-yl]-piperidine(203186-02-1)

Safety Data

• Hazardous Substances Data: 203186-02-1(Hazardous Substances Data)

Upstream product

• 126501-70-0 1-(2,2,2-trifluoroacetyl)piperidine-4-carboxylic acid 
• 498-94-2 isonipecotic acid 
• 203187-77-3 1-{4-[2-(4-bromophenyl)-1,3-dioxolan-2-yl]piperidin-1-yl}-2,2,2-trifluoroethanone 
• 203186-01-0 1-[4-(4-bromobenzoyl)piperidin-1-yl]-2,2,2-trifluoroethanone 

Downstream Products

• 816448-92-7 4-[(E)-(4-bromophenyl)(ethoxyimino)methyl]-1-(4-methyl-4-piperidinyl)piperidine 
• 515881-16-0 4-[(Z)-(4-bromophenyl)(ethoxyimino)methyl]-1-(4-methyl-4-piperidinyl)-piperidine 
• 305794-45-0 4-(4-bromobenzoyl)-1'-(tert-butoxycarbonyl)-4'-methyl-1,4'-bipiperidine 
• 438207-92-2 4-[(4-bromo-phenyl)-ethoxyimino-methyl]-4'-methyl-[1,4']bipiperidinyl-1'-carboxylic acid tert-butyl ester 
• 438207-93-3 4-[(4-bromo-phenyl)-ethoxyimino-methyl]-4'-methyl-[1,4']bipiperidinyl-1'-carboxylic acid tert-butyl ester 
• 305794-43-8 4-[2-(4-bromophenyl)-1,3-dioxolan-2-yl]-1'-(tert-butoxycarbonyl)-4'-methyl-1,4'-bipiperidine 
• 370893-06-4 ancriviroc 

Relevant articles and documents

PIPERIDINE DERIVATIVES USEFUL AS CCR5 ANTAGONISTS

Pharmaceutical compositions for the treatment of HIV are provided comprising compounds of formula (II) or a pharmaceutically acceptable salt or isomer thereof, in combination with specified antiviral agents.

Synthesis, SAR, and biological evaluation of oximino-piperidino-piperidine amides. 1. Orally bioavailable CCR5 receptor antagonists with potent anti-HIV activity

We previously reported the discovery of 4-[(Z)-(4-bromophenyl)(ethoxyimino)methyl]-1′-[(2,4-dimethyl-3 -pyridinyl)carbonyl]-4′-methyl-1,4′-bipipefidine N-oxide 1 (SCH 351125) as an orally bioavailable human CCR5 antagonist for the treatment of HIV-1 infec