20324-51-0

Basic information

• Product Name: 2-Chloro-6-mercaptobenzoic acid
• Synonyms: 2-Chloro-6-mercaptobenzoic acid;Benzoic acid, 2-chloro-6-Mercapto-;6-Chloro-2-mercaptobenzoic acid;2-Mercapto-6-Chloro Benzoic Acid
• CAS NO: 20324-51-0
• Molecular Formula: C₇H₅ClO₂S
• Molecular Weight: 188.6314
• EINECS: 1312995-182-4
• Mol File: 20324-51-0.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 323.2±27.0 °C(Predicted)
• Appearance: /
• Density: 1.490
• PKA: 2.35±0.36(Predicted)
• CAS DataBase Reference: 2-Chloro-6-mercaptobenzoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Chloro-6-mercaptobenzoic acid(20324-51-0)
• EPA Substance Registry System: 2-Chloro-6-mercaptobenzoic acid(20324-51-0)

Safety Data

• Hazardous Substances Data: 20324-51-0(Hazardous Substances Data)

Usage

General Description

2-Chloro-6-mercaptobenzoic acid is a chemical compound with the molecular formula C7H5ClO2S. It is an organochlorine compound that contains a thiol group, which gives it strong odor and makes it highly reactive. 2-Chloro-6-mercaptobenzoic acid is commonly used in organic synthesis and chemical research as a building block for creating other organic compounds. It has also been studied for its potential biological activities, including its antibacterial and anticancer properties. Due to its reactivity and potential health hazards, it should be handled and stored with care in a controlled laboratory environment.

Synthetic route

6-chloro-2-[ethoxy(thiocarbonyl)-thio]benzoic acid (144988-64-7) → 2-chloro-6-mercapto-benzoic acid (20324-51-0)

Conditions	Yield
With sodium hydroxide In methanol

Upstream product

• 144988-64-7 6-chloro-2-[ethoxy(thiocarbonyl)-thio]benzoic acid 

Downstream Products

• 123342-93-8 2-chloro-6-[(4,6-dimethoxypyrimidin-2-yl)thio]benzoic acid 

Relevant articles and documents

Herbicidal substituted benzoylsulfonamides

Compound of the formula STR1 in which A is O, S, or NR3 ; G is CH or N; R and R1 are independently alkyl, alkoxy, haloalkoxy or alkylamino; R2 is phenyl, substituted phenyl, alkyl, cycloalkyl, haloalkyl or --CH2 [(R4)C(R5)n --Z; R3 and R7 are, independently, hydrogen, alkyl, --C(O)NH2 or --C(O)alkyl; R4 and R5 are independently hydrogen, alkyl, or halogen; R6 is halogen, alkyl, alkoxy, haloalkoxy, NO2, amino, alkyl substituted amino, or acyl substituted amino; n is 0 to 5; Z is cyano, amino, alkylamino, dialkylamino, --NHCO2 alkyl, alkoxy, alkylthio, alkylsulfonyl, alkenyl, alkynyl, phenyl or substituted phenyl; and Q is hydrogen, halogen, alkyl, alkoxy, haloalkoxy, nitro, amino, haloalkyl, alkythio, alkylsulfonyl, phenyl, substituted phenyl or phenoxy; or a 5 or 6 membered aromatic heterocycle having the formula STR2 in which "m" is 0 or 1; A' is O, S, or NR7 ; and X, X', Y, Y', W, W', V, V', U and Z' are independently N, O, S, --CH-- or --CR6. Intermediates for preparation of the benzoylsulfonamides are also disclosed.