203259-42-1

Basic information

• Product Name: 4-(4-Acetylamino-phenyl)-2-hydroxy-3-methyl-4-oxo-butyric acid
• CAS NO: 203259-42-1
• Molecular Weight: 265.266
• Mol File: 203259-42-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 4-(4-Acetylamino-phenyl)-2-hydroxy-3-methyl-4-oxo-butyric acid(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(4-Acetylamino-phenyl)-2-hydroxy-3-methyl-4-oxo-butyric acid(203259-42-1)
• EPA Substance Registry System: 4-(4-Acetylamino-phenyl)-2-hydroxy-3-methyl-4-oxo-butyric acid(203259-42-1)

Safety Data

• Hazardous Substances Data: 203259-42-1(Hazardous Substances Data)

Upstream product

• 16960-49-9 N-(4-propionylphenyl)acetamide 
• 298-12-4 Glyoxilic acid 

Downstream Products

• 203259-43-2 4-(4-Acetylamino-phenyl)-2-hydroxy-3-methyl-4-oxo-butyric acid methyl ester 
• 203259-45-4 (E)-4-(4-Acetylamino-phenyl)-3-methyl-4-oxo-but-2-enoic acid methyl ester 
• 203259-44-3 4-(4-Acetylamino-phenyl)-2-methanesulfonyloxy-3-methyl-4-oxo-butyric acid methyl ester 

Relevant articles and documents

Studies on agents with vasodilator and β-blocking activities. V. Synthesis and pharmacological activity of the optical isomers of TZC-5665

Synthesis of the four optical isomers of TZC-5665 (1), a candidate for the treatment of congestive heart failure, was achieved by the reaction of chiral diaminopyridazinone (2) with chiral glycidyl ether (3). The hypotensive and β-blocking activities of 1 and its optical isomers were examined when given intravenously into anesthetized rats. Furthermore these compounds were evaluated for inhibitory activity on cAMP phosphodiesterase III. Among the four optical isomers, R(A),S(B)-one (1c) possessed the essential activities of TZC-5665 (1).