203302-92-5

Basic information

• Product Name: 3-BROMO-2-CHLORO-6-FLUOROTOLUENE
• Synonyms: 1-bromo-2-chloro-4-fluoro-3-methylbenzene;2-Chloro-3-bromo-6-fluorotoluene;3-Bromo-2-chloro-6-fluorotoluene;1-broMo-3-chloro-2,4-diMethylbenzene
• CAS NO: 203302-92-5
• Molecular Formula: C₇H₅BrClF
• Molecular Weight: 223.47
• Product Categories: Pharmaceutical intermediate
• Mol File: 203302-92-5.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 219.5 °C at 760 mmHg
• Flash Point: 86.6 °C
• Appearance: /
• Density: 1.618 g/cm³
• Vapor Pressure: 0.176mmHg at 25°C
• Refractive Index: 1.545
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 3-BROMO-2-CHLORO-6-FLUOROTOLUENE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-BROMO-2-CHLORO-6-FLUOROTOLUENE(203302-92-5)
• EPA Substance Registry System: 3-BROMO-2-CHLORO-6-FLUOROTOLUENE(203302-92-5)

Safety Data

• Hazard Codes: Xi,Xn
• Hazardous Substances Data: 203302-92-5(Hazardous Substances Data)

Usage

General Description

3-Bromo-2-Chloro-6-Fluorotoluene is a specialized chemical compound containing bromine, chlorine, and fluorine groups attached to a toluene molecule. The term 'toluene' refers to a type of hydrocarbon, which is essentially made up of hydrogen and carbon. The specific arrangement of these atoms - bromine at the third position, chlorine at the second position, and fluorine at the sixth position - is what gives this compound its unique properties, which can be utilized in various chemical reactions. Due to its complex structure, it is often used in specialized industrial or research settings. Its data regarding potential health effects or environmental impact is limited, like many specialized chemicals, and should be handled with care, following appropriate safety guidelines.

InChI:InChI=1/C7H5BrClF/c1-4-6(10)3-2-5(8)7(4)9/h2-3H,1H3

Upstream product

• 443-83-4 2-chloro-6-fluorotoluene 

Downstream Products

• 1003608-90-9 1-bromo-3-bromomethyl-2-chloro-4-fluoro-benzene 
• 796600-15-2 2-chloro-4-fluoro-3-methylbenzonitrile 
• 1003608-91-0 (3-bromo-2-chloro-6-fluoro-phenyl)-acetonitrile 
• 1003608-92-1 (3-bromo-2-chloro-6-fluoro-phenyl)-acetic acid 

Relevant articles and documents

Synthesis, structure-activity relationships, and characterization of novel nonsteroidal and selective androgen receptor modulators

Herein we describe the discovery of ACP-105 (1), a novel and potent nonsteroidal selective androgen receptor modulator (SARM) with partial agonist activity relative to the natural androgen testosterone. Compound 1 was developed from a series of compounds found in a HTS screen using the receptor selection and amplification technology (R-SAT). In vivo, 1 improved anabolic parameters in a 2-week chronic study in castrated male rats. In addition to compound 1, a number of potent antiandrogens were discovered from the same series of compounds whereof one compound, 13, had antagonist activity at the AR T877A mutant involved in prostate cancer.