20354-32-9Relevant articles and documents
Oligonucleotides having phosphorothioate linkages of high chiral purity.
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, (2008/06/13)
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Compounds having phosphorodithioate linkages of high chiral purity
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, (2008/06/13)
Sequence-specific phosphorothioate oligonucleotides comprising nucleoside units which are joined together by either substantially all Sp or substantially all Rp phosphorothioate intersugar linkages are provided. Such sequence-specific phosphorothioate oligonucleotides having substantially chirally pure intersugar linkages are prepared by enzymatic or chemical synthesis. Sequence-specific phosphorodithioate oligonucleotides are also provided. Such sequence-specific phosphorodithioate oligonucleotides are prepared by chemical synthesis. They are especially well suited as diagnostics, therapeutics and research reagents.
Oligonucleotides having phosphorothioate linkages of high chiral purity for therapeutic modulation of Ha-ras or Ki-ras genes.
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, (2008/06/13)
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