20372-72-9

Basic information

• Product Name: Benzene, (2-chloro-1-fluoroethyl)-
• CAS NO: 20372-72-9
• Molecular Formula: C8H8ClF
• Molecular Weight: 158.603
• Mol File: 20372-72-9.mol
• Article Data: 8

Chemical Properties

• CAS DataBase Reference: Benzene, (2-chloro-1-fluoroethyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzene, (2-chloro-1-fluoroethyl)-(20372-72-9)
• EPA Substance Registry System: Benzene, (2-chloro-1-fluoroethyl)-(20372-72-9)

Safety Data

• Hazardous Substances Data: 20372-72-9(Hazardous Substances Data)

Upstream product

• 100-42-5 styrene 
• 593-78-2 methyl hypochlorite 
• 1674-30-2 1-phenyl-2-chloroethanol 
• 622-24-2 2-phenylethyl chloride 
• 7651-91-4 N,N-dichloromethylamine 
• 666-23-9 phenyltetrafluorophosphorane 
• 36402-34-3 1-chloro-2-phenyl-2-(trimethylsiloxy)ethane 
• 2932-58-3 2-fluoro-2-phenylethanol 

Downstream Products

• 696-31-1 α-fluorostyrene 

Relevant articles and documents

Visible light-promoted metal-free C-H activation: Diarylketone-catalyzed selective benzylic mono- and difluorination

We report herein an operationally simple method for the direct conversion of benzylic C-H groups to C-F. We show that visible light can activate diarylketones to abstract a benzylic hydrogen atom selectively. Adding a fluorine radical donor yields the benzylic fluoride and regenerates the catalyst. The selective formation of mono- and difluorination products can be achieved by catalyst control. 9-Fluorenone catalyzes benzylic C-H monofluorination, while xanthone catalyzes benzylic C-H difluorination. The scope and efficiency of this new C-H fluorination method are significantly better than those of the existing methods. This is also the first report of selective C-H gem-difluorination.

Fluorination with ionic liquid EMIMF(HF)2.3 as mild HF source

Hydrogen fluoride is a basic fluorinating reagent, but handling it is difficult. For this reason, some modified fluorinating reagents such as HF-pyridine, Et3N-HF, and poly(hydrogen fluoride) complex have been developed. Those reagents, however, still require aqueous work-up procedures which generate hydrogen fluoride. Recently, ionic liquids have received much attention because of the ease in handling them and the possibility of non-aqueous work-up. An ionic liquid, 3-ethyl-1-methyimidazolium oligo hydrogen fluoride (EMIMF(HF)2.3), which is stable in air and moisture, can be used as a hydrogen fluoride equivalent for some fluorination reactions; it does not require an aqueous work-up.

TETRABUTYLAMMONIUM DIHYDROGENTRIFLUORIDE: AN EFFECTIVE SOURCE OF FLUORIDE ION FOR HALOFLUORINATION OF ALKENES

Vicinal halofluorides have been prepared from the corresponding alkenes by reaction with a stoichiometric amount of Bu4N+H2F3- as a source of fluoride anion and an excess of an N-halosuccinimide (NXS).The reaction products are obtained in good yields, with a prevalent Markownikoff regiochemistry.Olefins containing hydroxy, epoxy, acetoxy and alkoxy groups do not undergo side reactions under these reaction conditions.