203730-22-7

Basic information

• Product Name: (3R,4S)-3,4-bis(benzyloxy)pyrrolidin-2-one
• Synonyms: (3R,4S)-3,4-bis(benzyloxy)pyrrolidin-2-one
• CAS NO: 203730-22-7
• Molecular Weight: 297.354
• Mol File: 203730-22-7.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: (3R,4S)-3,4-bis(benzyloxy)pyrrolidin-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: (3R,4S)-3,4-bis(benzyloxy)pyrrolidin-2-one(203730-22-7)
• EPA Substance Registry System: (3R,4S)-3,4-bis(benzyloxy)pyrrolidin-2-one(203730-22-7)

Safety Data

• Hazardous Substances Data: 203730-22-7(Hazardous Substances Data)

Upstream product

• 203730-19-2 ((3R,4S,5R)-3,4-Bis-benzyloxy-5-benzyloxymethyl-tetrahydro-furan-2-yl)-(4-methoxy-benzyl)-amine 
• 197716-38-4 2,3,5-tri-O-benzyl-1-O-methyl-D-xylofuranoside 
• 16838-89-4 2,3,5-tri-O-benzyl-D-xylofuranose 
• 41341-99-5 3,5-di-O-benzyl-1,2-O-isopropylidene-α-D-xylofuranose 
• 102339-30-0 (3R,4R,5R)-4-(benzyloxy)-5-(benzyloxymethyl)-2-methoxytetrahydrofuran-3-ol 
• 203730-21-6 (3R,4S)-3,4-Bis-benzyloxy-1-(4-methoxy-benzyl)-pyrrolidin-2-one 

Downstream Products

• 191849-98-6 (2S,3R,4R)-3,4-bis(benzyloxy)-N-tert-butylpyrrolidine-2-carboxamide 
• 1400236-11-4 (1S,2S,8aS)-1,2-bis(benzyloxy)-2,3,8,8a-tetrahydroindolizin-7(1H)-one 
• 203730-24-9 (3R,4S)-3,4-Bis-benzyloxy-2-oxo-pyrrolidine-1-carboxylic acid tert-butyl ester 

Relevant articles and documents

Synthesis of polyhydroxylated quinolizidine and indolizidine scaffolds from sugar-derived lactams via a one-pot reduction/Mannich/Michael sequence

A direct approach to the synthesis of indolizidine and quinolizidine scaffolds of iminosugars is described. The presented strategy is based on a one-pot sugar lactam reduction with Schwartz's reagent followed by a diastereoselective Mannich/Michael tandem reaction of the resulting sugar imine with Danishefsky's diene. The stereochemical course of the investigated reaction has been explained in detail. The obtained bicyclic products are attractive building blocks for the synthesis of various naturally occurring polyhydroxylated alkaloids and their derivatives.