203866-21-1 Usage
Description
(2S)-Fmoc-4,4-difluoro-pyrrolidine-2-carboxylic acid is a chemical compound with a molecular formula C18H19F2NO4. It is a derivative of pyrrolidine-2-carboxylic acid, featuring a fluorine substitution at the 4th position of the pyrrolidine ring. (2S)-Fmoc-4,4-difluoro-pyrrolidine-2-carboxylic acid is characterized by the presence of the Fmoc (9-fluorenylmethyloxycarbonyl) protecting group, which is instrumental in peptide chemistry for its selective deprotection capabilities under mild conditions. It serves as a crucial building block in the synthesis of peptide and protein-based pharmaceuticals, playing a significant role in medicinal and pharmaceutical research.
Uses
Used in Pharmaceutical Synthesis:
(2S)-Fmoc-4,4-difluoro-pyrrolidine-2-carboxylic acid is utilized as a key building block for the synthesis of peptide and protein-based pharmaceuticals. Its incorporation into these biologically active molecules allows for the development of new drugs with potential therapeutic applications.
Used in Solid-Phase Peptide Synthesis:
In the field of solid-phase peptide synthesis, (2S)-Fmoc-4,4-difluoro-pyrrolidine-2-carboxylic acid is employed as a component that protects the amine group in the peptide chain. This protection is vital for preventing unwanted side reactions during the synthesis process, thereby ensuring the production of the desired peptide sequence.
Used in Medicinal Research:
(2S)-Fmoc-4,4-difluoro-pyrrolidine-2-carboxylic acid is also used in medicinal research as a versatile tool for the exploration of novel drug candidates. Its unique structure and the ability to selectively deprotect the amine group make it an attractive candidate for the design and synthesis of new pharmaceutical agents.
Check Digit Verification of cas no
The CAS Registry Mumber 203866-21-1 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,0,3,8,6 and 6 respectively; the second part has 2 digits, 2 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 203866-21:
(8*2)+(7*0)+(6*3)+(5*8)+(4*6)+(3*6)+(2*2)+(1*1)=121
121 % 10 = 1
So 203866-21-1 is a valid CAS Registry Number.
203866-21-1Relevant articles and documents
Inhibitors of caspases
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, (2008/06/13)
The present invention relates to novel classes of compounds which are caspase inhibitors, in particular interleukin-1β converting enzyme (“ICE”) inhibitors. This invention also relates to pharmaceutical compositions comprising these compounds. The compounds and pharmaceutical compositions of this invention are particularly well suited for inhibiting caspase activity and consequently, may be advantageously used as agents against interleukin-1-(“IL-1”), apoptosis-, interferon-γ inducing factor-(IGIF), or interferon-γ-(“IFN-γ”) mediated diseases, including inflammatory diseases, autoimmune diseases, destructive bone disorders, proliferative disorders, infectious diseases, and degenerative diseases. This invention also relates to methods for inhibiting caspase activity and decreasing IGIF production and IFN-γ production and methods for treating interleukin-1, apoptosis-, and interferon-γ-mediated diseases using the compounds and compositions of this invention. This invention also relates to methods of preparing the compounds of this invention.
