203872-24-6Relevant articles and documents
Isoxazolinoisoquinoline Heterocycles via Solid-Phase Reinsert and Suzuki Reactions
Lorsbach, Beth A.,Bagdanoff, Jeffrey T.,Bryan Miller,Kurth, Mark J.
, p. 2244 - 2250 (2007/10/03)
A traceless solid-phase synthesis strategy has been developed that delivers novel isoxazolinoisoquinoline heterocycles. The process consists of solid-phase Reissert formation (isoquinoline → I), Suzuki coupling lithiation, and subsequent C1-alkylation (I → II), and exo-olefin selective 1,3-dipolar nitrile oxide cycloaddition followed by Reissert hydrolysis (II → III) to liberate the targeted heterocycle.