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203916-59-0

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203916-59-0 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 203916-59-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,0,3,9,1 and 6 respectively; the second part has 2 digits, 5 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 203916-59:
(8*2)+(7*0)+(6*3)+(5*9)+(4*1)+(3*6)+(2*5)+(1*9)=120
120 % 10 = 0
So 203916-59-0 is a valid CAS Registry Number.

203916-59-0SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 20, 2017

Revision Date: Aug 20, 2017

1.Identification

1.1 GHS Product identifier

Product name 2,3,4-trifluoro-5-iodobenzoic acid

1.2 Other means of identification

Product number -
Other names 5-IODO-2,3,4-TRIFLUOROBENZOIC ACID

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:203916-59-0 SDS

203916-59-0Relevant articles and documents

Halogen Bonding Directed Supramolecular Quadruple and Double Helices from Hydrogen-Bonded Arylamide Foldamers

Liu, Chuan-Zhi,Koppireddi, Satish,Wang, Hui,Zhang, Dan-Wei,Li, Zhan-Ting

, p. 226 - 230 (2019)

Halogen bonding has been used to glue together hydrogen-bonded short arylamide foldamers to achieve new supramolecular double and quadruple helices in the solid state. Three compounds, which bear a pyridine at one end and either a CF2I or fluor

Design and synthesis of novel allosteric MEK inhibitor CH4987655 as an orally available anticancer agent

Isshiki, Yoshiaki,Kohchi, Yasunori,Iikura, Hitoshi,Matsubara, Yasuaki,Asoh, Kohsuke,Murata, Takeshi,Kohchi, Masami,Mizuguchi, Eisaku,Tsujii, Shinji,Hattori, Kazuo,Miura, Takaaki,Yoshimura, Yasushi,Aida, Satoshi,Miwa, Masanori,Saitoh, Ryoichi,Murao, Naoaki,Okabe, Hisafumi,Belunis, Charles,Janson, Cheryl,Lukacs, Christine,Schück, Verena,Shimma, Nobuo

scheme or table, p. 1795 - 1801 (2011/05/11)

The MAP kinase pathway is one of the most important pathways involved in cell proliferation and differentiation, and its components are promising targets for antitumor drugs. Design and synthesis of a novel MEK inhibitor, based on the 3D-structural information of the target enzyme, and then multidimensional optimization including metabolic stability, physicochemical properties and safety profiles were effectively performed and led to the identification of a clinical candidate for an orally available potent MEK inhibitor, CH4987655, possessing a unique 3-oxo-oxazinane ring structure at the 5-position of the benzamide core structure. CH4987655 exhibits slow dissociation from the MEK enzyme, remarkable in vivo antitumor efficacy both in mono- and combination therapy, desirable metabolic stability, and insignificant MEK inhibition in mouse brain, implying few CNS-related side effects in human. An excellent PK profile and clear target inhibition in PBMC were demonstrated in a healthy volunteer clinical study.

5-SUBSTITUTED-2-PHENYLAMINO-BENZAMIDE AS MEK INHIBITOR

-

Page/Page column 73, (2008/06/13)

An objective of the present invention is to provide compounds that exhibit strong MEK-inhibiting activity and are stable in vivo and soluble in water, which can be used as preventive or therapeutic agents for proliferative diseases. The compounds of the present invention and pharmaceutically acceptable salts thereof are represented by the following formula (1): [where R1, R2, R3, R4, and X are the same as defined in the present patent application].

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