20408-97-3 Usage
Description
5-Thio-D-glucose (CAS# 20408-97-3) is a chemical compound that serves as a potent competitive inhibitor of the cellular transport of glucose and glucose-mediated insulin release. It is characterized by its ability to induce a state of glucose deprivation in laboratory animals and has been observed to stimulate feeding in rat models. Additionally, it has been linked to inducing Alzheimer-like changes in the frontal cortex and hippocampus of rats and elevating renal TGF-b1 levels at specific doses.
Uses
1. Used in Organic Synthesis:
5-Thio-D-glucose is utilized as a compound in organic synthesis, contributing to the development of various chemical products and materials.
2. Used in Research and Development:
5-Thio-D-glucose is used as a research tool to study the effects of glucose deprivation on cellular processes and insulin release. It helps researchers understand the underlying mechanisms and potential therapeutic targets for conditions related to glucose metabolism and insulin function.
3. Used in Pharmaceutical Research:
The compound is employed in pharmaceutical research to investigate its potential as a therapeutic agent for conditions such as diabetes and Alzheimer's disease. Its ability to induce glucose deprivation and stimulate feeding in rat models makes it a valuable tool for exploring novel treatment strategies.
4. Used in Nutritional Studies:
5-Thio-D-glucose is used in nutritional studies to examine the effects of glucose deprivation on feeding behavior and energy metabolism. This information can be crucial for developing strategies to address obesity and other metabolic disorders.
5. Used in Neurological Research:
The compound is utilized in neurological research to investigate its potential role in inducing Alzheimer-like changes in the brain. This can help researchers better understand the disease's progression and develop targeted therapies for Alzheimer's patients.
6. Used in Diabetes Research:
5-Thio-D-glucose is employed in diabetes research to study its effects on renal TGF-b1 levels and its potential to prevent streptozotocin-induced diabetes in rats. This information can be valuable for developing new treatments and managing diabetes-related complications.
References
Wang et al. (1995) Glucose transporter 2 expression: prevention of streptozotocin-induced reduction in beta-cells with 5-thio-D-glucose; Clin. Endocrinol. Diabetes, 103 83 Suppl.2
Shah et al. (2019), Recurrent glucose deprivation leads to the preferential use of lactate by neurons in the ventromedial hypothalamus; J. Physiol. Endocrinol. Metab., 316 E948
Li et al. (2014), Stimulation of feeding by three different glucose-sensing mechanisms requires hindbrain catecholamine neurons; J. Physiol. Regul. Integr. Comp. Physiol., 306 R257
Salkovic-Petrisic et al. (2006), Alzheimer-like changes in protein kinase B and glycogen synthase kinase-3 in rat frontal cortex and hippocampus after damage to the insulin signaling pathway; J. Neurochem., 96 1005
Lane et al. (2000), 5-thio-D-glucose elevates renal transforming growth factor beta-1 at a dose that does not prevent streptozotocin diabetes in rats; Endocrinology, 141 3337
Check Digit Verification of cas no
The CAS Registry Mumber 20408-97-3 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,0,4,0 and 8 respectively; the second part has 2 digits, 9 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 20408-97:
(7*2)+(6*0)+(5*4)+(4*0)+(3*8)+(2*9)+(1*7)=83
83 % 10 = 3
So 20408-97-3 is a valid CAS Registry Number.
InChI:InChI=1/C6H12O5S/c7-1-2-3(8)4(9)5(10)6(11)12-2/h2-11H,1H2/t2-,3-,4+,5-,6+/m1/s1
