204205-90-3 Usage
Description
2-(1-(4-Chlorophenylmethyl)-1H-indol-3-yl)-2-oxo-N-(pyridin-4-yl)acetamide, also known as Indibulin, is a synthetic compound with a unique chemical structure that features a 1H-indol-3-yl group connected to a 4-chlorophenylmethyl moiety and a pyridin-4-ylacetamide group. It is a microtubule destabilizer, which means it interferes with the normal function of microtubules in cells, leading to the inhibition of cell division and ultimately cell death.
Uses
Used in Pharmaceutical Industry:
Indibulin is used as a chemotherapeutic drug for the treatment of breast cancer and other heterogeneous and aggressive types of cancer. Its microtubule destabilizing properties make it effective in targeting and killing cancer cells, particularly those that are resistant to conventional chemotherapy.
The specific application reason for Indibulin's use in cancer treatment is its ability to disrupt the normal function of microtubules, which are essential for cell division and maintaining cell structure. By inhibiting microtubule function, Indibulin prevents cancer cells from dividing and proliferating, leading to their eventual death. This makes it a valuable tool in the fight against various types of cancer, particularly those that are difficult to treat with standard chemotherapy drugs.
Biological Activity
Microtubule destabilizer that blocks tubulin polymerization (IC 50 = 0.3 μ M). Blocks cell cycle progression at metaphase and displays antitumor activity against a variety of malignancies in vitro (IC 50 values ranging from 0.036-0.285 μ M). Induces complete tumor remission in the Yoshida AH13 rat sarcoma model in vivo . Lacks neurotoxicity due to an ability to discriminate between posttranslationally modified tubulin in mature neuronal microtubules and less-modified tubulin present in immature neuronal or nonneuronal microtubules. Displays oral availability and efficacy towards MDR tumor cells.
Check Digit Verification of cas no
The CAS Registry Mumber 204205-90-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,0,4,2,0 and 5 respectively; the second part has 2 digits, 9 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 204205-90:
(8*2)+(7*0)+(6*4)+(5*2)+(4*0)+(3*5)+(2*9)+(1*0)=83
83 % 10 = 3
So 204205-90-3 is a valid CAS Registry Number.
InChI:InChI=1/C22H16ClN3O2/c23-16-7-5-15(6-8-16)13-26-14-19(18-3-1-2-4-20(18)26)21(27)22(28)25-17-9-11-24-12-10-17/h1-12,14H,13H2,(H,24,25,28)