204326-24-9 Usage
Description
Azepino[3,2,1-hi]indole-2-carboxylic acid, 1,2,4,5,6,7-hexahydro-5-[[(9H-fluoren-9-ylmethoxy)carbonyl]amino]-4-oxo-, (2S,9S)-(9CI) is a complex organic compound with a unique chemical structure. It is characterized by its white to off-white powder appearance and is primarily known for its role in the preparation of phosphopeptide inhibitors of STAT3.
Uses
Used in Pharmaceutical Industry:
Azepino[3,2,1-hi]indole-2-carboxylic acid, 1,2,4,5,6,7-hexahydro-5-[[(9H-fluoren-9-ylmethoxy)carbonyl]amino]-4-oxo-, (2S,9S)-(9CI) is used as a key intermediate in the synthesis of phosphopeptide inhibitors for the protein STAT3. These inhibitors play a crucial role in regulating cellular processes such as cell growth, differentiation, and apoptosis, making them valuable in the development of targeted therapies for various diseases, including cancer.
Used in Research and Development:
In addition to its pharmaceutical applications, Azepino[3,2,1-hi]indole-2-carboxylic acid, 1,2,4,5,6,7-hexahydro-5-[[(9H-fluoren-9-ylmethoxy)carbonyl]amino]-4-oxo-, (2S,9S)-(9CI) is also utilized in research and development settings. It serves as a valuable tool for studying the structure, function, and regulation of STAT3 and other related proteins, contributing to a deeper understanding of their roles in cellular processes and disease mechanisms.
Used in Drug Design and Optimization:
The compound is also employed in the field of drug design and optimization, where it can be used to develop novel inhibitors or modify existing ones to improve their potency, selectivity, and pharmacokinetic properties. This application is particularly relevant in the context of cancer research, where the development of more effective and targeted therapies is of utmost importance.
Check Digit Verification of cas no
The CAS Registry Mumber 204326-24-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,0,4,3,2 and 6 respectively; the second part has 2 digits, 2 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 204326-24:
(8*2)+(7*0)+(6*4)+(5*3)+(4*2)+(3*6)+(2*2)+(1*4)=89
89 % 10 = 9
So 204326-24-9 is a valid CAS Registry Number.
204326-24-9Relevant articles and documents
Conformationally constrained peptidomimetic inhibitors of Signal transducer and activator of transcription 3: Evaluation and molecular modeling
Mandal, Pijus K.,Limbrick, Donald,Coleman IV, David R.,Dyer, Garrett A.,Ren, Zhiyong,Birtwistle, J. Sanderson,Xiong, Chiyi,Chen, Xiaomin,Briggs, James M.,McMurray, John S.
experimental part, p. 2429 - 2442 (2010/03/01)
Signal transducer and activator of transcription 3 (Stat3) is involved in aberrant growth and survival signals in malignant tumor cells and is a validated target for anticancer drug design. We are targeting its SH2 domain to prevent docking to cytokine an
