204511-52-4Relevant articles and documents
A novel one-pot synthesis of 2-arylpyrazoloquinolinone derivatives
Chang, En-Chiuan,Wen, Ya-Lan,Chang, Chun-Hsi,Shen, Yun-Hwei,Wen, Shaw-Bing,Yeh, Mou-Yung,Wong, Fung Fuh
supporting information; experimental part, p. 5920 - 5924 (2012/09/07)
Two regioisomers of 2-arylpyrazolo[3,4-c]quinolin-4(5H)-ones and 2-arylpyrazolo[4,3-c]quinolin-4(5H)-ones were synthesized by utilizing 3-arylsydnones, ethyl 3-bromopropynoate, and 2-aminophenylboronic acid pinacol ester in presence of catalytic agent Pd(PPh3)4. This efficient one-pot synthesis methodology involved 1,3-dipolar cycloaddition, Suzuki coupling reaction, and intramolecular cyclization three sequence steps.
Tricyclic heteroaromatic systems. Pyrazolo[3,4-c]quinolin-4-ones and pyrazolo[3,4-c]quinoline-1,4-diones: Synthesis and benzodiazepine receptor activity
Catarzi, Daniela,Colotta, Vittoria,Varano, Flavia,Cecchi, Lucia,Filacchioni, Guido,Galli, Alessandro,Costagli, Chiara
, p. 383 - 386 (2007/10/03)
Some pyrazolo[3,4-c]quinoline-4-ones 1-14 and pyrazolo[3,4-c]-quinoline-1,4-diones 15-17 were prepared and biologically evaluated for their binding at the benzodiazepine receptor (BZR) in rat cortical membranes. The moderate binding activity of 1-5, 7, 9-10, 13 is attributable to the lack of the optional proton acceptor at position-1, while the inactivity of the 1,4-dione derivatives 15-17 is due to the lack of the essential proton acceptor at position-3. These conclusions confirm the validity of our proposed pharmacophoric model.
