2046-23-3Relevant articles and documents
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Carr,D.B.,Schwartz,J.
, p. 3521 - 3531 (1979)
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Reactions of diazoalkanes with unsaturated compounds 15. Catalytic reactions of unsaturated carbonyl compounds and their derivatives with diazomethane
Khanova,Sultanova,Zlotskii,Dokichev,Tomilov
, p. 1003 - 1007 (2007/10/03)
The present study concerned with the influence of the nature of the acetal fragment in unsaturated compounds on the reactivity of the C=C bond in cyclopropanation reactions with diazomethane catalyzed by copper and palladium compounds. The acetal substitu
18-Cycloalkyl Analogues of Enisoprost
Collins, Paul W.,Gasiecki, Alan F.,Perkins, Willam E.,Gullikson, Gary W.,Jones, Peter H.,Bauer, Raymond F.
, p. 1001 - 1006 (2007/10/02)
By use of standard cuprate methodology, a series of 18-cycloalkyl analogues of enisoprost was prepared in an effort to impede ω chain metabolism and prolong duration of gastric antisecretory activity.An initial product of ω chain oxidation, the C-20 hydroxy analogue, was also synthesized for pharmacological comparison.The cyclopropyl, cyclobutyl, and cyclopentyl analogues were approximately one-fourth as potent as enisoprost in inhibiting gastric acid secretion, while the cyclohexyl and cycloheptyl analogues showed very weak activity, and the 20-hydroxy compound was inactive at a dose 100 times the ED 50 of enisoprost.The cyclobutyl compound had a longer duration of antisecretory action than enisoprost and the other cycloalkyl analogues.The cycloalkyl analogues unexpectedly possessed low diarrheogenic activity in rats.
