20461-34-1

Basic information

• Product Name: 1-chloro-1-phenylpropan-2-amine
• Synonyms: 1-chloro-1-phenylpropan-2-amine
• CAS NO: 20461-34-1
• Molecular Weight: 169.654
• Mol File: 20461-34-1.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 1-chloro-1-phenylpropan-2-amine(CAS DataBase Reference)
• NIST Chemistry Reference: 1-chloro-1-phenylpropan-2-amine(20461-34-1)
• EPA Substance Registry System: 1-chloro-1-phenylpropan-2-amine(20461-34-1)

Safety Data

• Hazardous Substances Data: 20461-34-1(Hazardous Substances Data)

Upstream product

• 1485-13-8 cis-2-Phenyl-3-methylaziridine 
• 873-66-5 1-propenylbenzene 
• 154-41-6 norephedrine hydrochloride 
• 18368-11-1 diethyl N,N-dichlorophosphoroamidate 
• 766-90-5 cis-1-phenyl-1-propylene 

Downstream Products

• 39663-75-7 (+/-)-cis-4-methyl-5-phenyloxazolidin-2-one 

Relevant articles and documents

Stereoselective c(sp3)-c(sp2) negishi coupling of (2-amido-1-phenylpropyl)zinc compounds through the steric control of β-amido group

A controllable diastereoselective C(sp2)-C(sp3) Negishi coupling reaction of secondary benzylic zinc reagents with aryl bromides has been demonstrated for the first time, forming medicinally important 1-arylphenylethylamines. In the presence of Pd(OAc)2 and S-phos, open-chain (2-amido-1-phenylethyl)zinc reagents bearing a β-NHAc or NHCHO group underwent cross-coupling reaction to give syn 1-arylphenylethylamine as the major products, whereas the zinc reagents bearing a sterically hindered β-NHCOC(CH3)2OTBS group specifically yielded anti 1-arylphenylethylamines.