204688-60-8

Basic information

• Product Name: (R)-N-Boc-3-pyrrolidineacetic acid
• Synonyms: (R)-3-CARBOXYMETHYL-PYRROLIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER;(R)-(1-BOC-PYRROLIDIN-3-YL)-ACETIC ACID;(R)-N-BOC-PYRROLIDINE-3-ACETIC ACID;(R)-N-BOC-3-PYRROLIDINEACETIC ACID;(R)-1-N-Boc-3-pyrrolidineacetic acid;(R)-1-Boc-3-pyrrolidineacetic acid;(R)-N-Boc-3-(R)-(1-Boc-Pyrrolidin-3-yl)-aceticacid;(R)-2-(1-(tert-Butoxycarbonyl)pyrrolidin-3-yl)acetic acid
• CAS NO: 204688-60-8
• Molecular Formula: C₁₁H₁₉NO₄
• Molecular Weight: 229.27
• Product Categories: pharmacetical
• Mol File: 204688-60-8.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 357.392 °C at 760 mmHg
• Flash Point: 169.945 °C
• Appearance: /
• Density: 1.151 g/cm³
• Vapor Pressure: 4.5E-06mmHg at 25°C
• Refractive Index: 1.491
• Storage Temp.: 2-8°C
• PKA: 4.65±0.10(Predicted)
• CAS DataBase Reference: (R)-N-Boc-3-pyrrolidineacetic acid(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-N-Boc-3-pyrrolidineacetic acid(204688-60-8)
• EPA Substance Registry System: (R)-N-Boc-3-pyrrolidineacetic acid(204688-60-8)

Safety Data

• Hazard Codes: T,N
• Statements: 25-50
• Safety Statements: 45-61
• RIDADR: UN2811
• Hazardous Substances Data: 204688-60-8(Hazardous Substances Data)

Usage

General Description

"(R)-N-Boc-3-pyrrolidineacetic acid" is a chemical compound that belongs to the category of pyrrolidine derivatives. It is a chiral compound, with the (R)- designation indicating its stereochemistry. The "N-Boc" in its name stands for N-tert-butoxycarbonyl, a protecting group commonly used in organic synthesis. (R)-N-Boc-3-pyrrolidineacetic acid is commonly used in organic synthesis as a building block for various pharmaceuticals, agrochemicals, and other fine chemicals. It is also used as a chiral auxiliary in asymmetric syntheses and in the preparation of peptidomimetics.

InChI:InChI=1/C11H19NO4/c1-11(2,3)16-10(15)12-5-4-8(7-12)6-9(13)14/h8H,4-7H2,1-3H3,(H,13,14)/t8-/m1/s1

Upstream product

• 24424-99-5 di-tert-butyl dicarbonate 
• 101385-93-7 3-oxo-pyrrolidine-1-carboxylic acid tert-butyl ester 
• 109431-87-0 (R)-tert-butyl 3-hydroxypyrrolidine-1-carboxylate 
• 1391730-27-0 tert-butyl (S)-3-(4-methylbenzenesulfonyloxymethyl)pyrrolidine-1-carboxylate 
• 138108-72-2 tert-butyl (R)-3-hydroxymethylpyrrolidine-1-carboxylate 
• 1187931-76-5 tert-butyl (S)-3-(cyanomethyl)pyrrolidine-1-carboxylate 
• 199174-24-8 tert-butyl (3S)-3-(hydroxymethyl)pyrrolidine-1-carboxylate 
• 1228312-12-6 2-((R)-1-tert-butoxycarbonyl-pyrrolidin-3-yl)-malonic acid diethyl ester 
• 127423-61-4 tert-butyl (3R)-3-methylsulfonyloxypyrrolidine-1-carboxylate 
• 1228312-13-7 2-((R)-1-tert-butoxycarbonyl-pyrrolidin-3-yl)-malonic acid 

Downstream Products

• 1212182-03-0 tert-butyl (3R)-3-(2-hydroxyethyl)pyrrolidine-1-carboxylate 
• 1228312-14-8 (R)-3-vinylpyrrolidine-1-carboxylic acid t-butyl ester 
• 274692-08-9 tert-butyl (3S)-3-(2-aminoethyl)pyrrolidine-1-carboxylate 
• 1332459-32-1 ethyl (R)-2-(pyrrolidin-3-yl)acetate hydrochloride 
• 1332332-66-7 4-[4-(1-benzofuran-5-yl)phenyl]-5-{[(3R)-1-(cyclopropylcarbonyl)-3-pyrrolidinyl]methyl}-2,4-dihydro-3H-1,2,4-triazol-3-one 
• 1332333-66-0 4-(4-bromophenyl)-5-{[(3R)-1-(cyclopropylcarbonyl)-3-pyrrolidinyl]methyl}-2,4-dihydro-3H-1,2,4-triazol-3-one 
• 1332333-65-9 N-(4-bromophenyl)-2-{[(3R)-1-(cyclopropylcarbonyl)-3-pyrrolidinyl]acetyl}hydrazinecarboxamide 
• 1024038-31-0 (R)-pyrrolidin-3-yl-acetic acid methyl ester hydrochloric acid salt 

Relevant articles and documents

Preparation method of R-N-Boc-3-pyrrolidine acetic acid

The invention provides a preparation method of R-N-Boc-3-pyrrolidine acetic acid, which comprises the following steps: by using N-Boc-3-pyrrolidone and trimethyl phosphonyl acetate as raw materials, carrying out wittig reaction, asymmetric reduction hydrogenation reaction and hydrolysis reaction to obtain the R-N-Boc-3-pyrrolidine acetic acid. The preparation method starts from a low-price racemicmixture N-Boc-3-pyrrolidone, the reaction conditions are mild, use of dangerous materials is not needed, the reaction steps are few, the process is simple, the single product R-N-Boc-3-pyrrolidine acetic acid with a target chiral structure can be finally obtained, the product has high purity, an optical activity ee value of more than 99% and high yield, and industrial scale-up production is facilitated.

BIARYL DERIVATIVE AS GPR120 AGONIST

The present invention relates to a biaryl derivative expressed by the chemical formula 1, a method for producing the biaryl derivative, a pharmaceutical composition comprising same, and use of same, the biaryl derivative expressed by the chemical formula 1, as a GPR120 agonist, promoting GLP-1 generation in the gastro-intestinal tract, reducing insulin resistance in the liver, muscles and the like from anti-inflammatory activity in the macrophage, pancreatic cells and the like, and allowing effective use in prevention or treatment of inflammation or metabolic diseases such as diabetes, complications from diabetes, obesity, non-alcoholic fatty liver disease, fatty liver disease, and osteoporosis.

NOVEL COMPOUNDS

The present invention relates to compounds that bind to and modulate the activity of neuronal nicotinic acetylcholine receptors, to novel salts thereof, to processes for preparing these compounds, novel chemical compounds useful as intermediates, pharmaceutical compositions containing the product compounds, and to methods of using these compounds for treating a wide variety of conditions and disorders, including those associated with dysfunction of the central nervous system (CNS).